Article
MORPHOLOGICAL CHANGES OF SENSORIMOTOR CORTEX AND HIPPOCAMPUS IN RATS OF DIFFERENT AGE AFTER TRAUMATIC BRAIN INJURY
About the author: | Mikhalsky S. A., Savitska D. V., Biloshytsky V. V., Kvitnitskaya-Ryzhova T. Yu. |
Heading | EXPERIMENTAL MEDICINE |
Type of article | Scentific article |
Annotation | In the model of severe traumatic brain injury (TBI) in adult and old Wistar rats we have demonstrated significant changes in the structure of sensorimotor cortex and hippocampus, resulting in a significant decrease in the number of neurons, growth of vacuolated hyperchromic nerve cells fraction and the sharp increase in the number of glia. Gene therapy by means of cationic liposome-mediated APOE3 transfer significantly decreased reactive gliosis and number of microgliocytes both in the cortex and in the hippocampus, and had a positive effect on the number of neurons, preventing their loss in adult and especially in old rats. |
Tags | traumatic brain injury, gene therapy, cortex, hippocampus, structural changes, morphometry, age characteristics |
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Publication of the article | «World of Medicine and Biology» №4(46) 1 part 2014 year, 120-126 pages, index UDK 591.481.1-001:57.012.4 |