| About the author: |
Bandurka N. M. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
This paper presents experimental results on 55 guinea pigs, which were triggered with cardiac arrhythmia caused by glycoside intoxication and studied the effectiveness of antiarrhythmic drugs in these circumstances. Established is that cardioprotective drug Trymetazidin and membrane protector Rhythmokor showed antiarrhythmic agent (43% (p <0.05) and 67% (p <0.05)), antifibrillator (57% (p <0.01) and 50% (p <0.05)) and cardioprotective (43% (p <0.05) and 67% (p <0.05), respectively) effects. Amiodarone had only cardio protector effect of -37% (p <0,05). The combination of amiodarone with Trymetazidin as the combination of amiodarone with antiarrhythmic Rhythmokor showed (50% (p <0.05) and 75% (p <0.001)), antifibrillator (50% (p <0.05) and 63% (p <0.01)) and cardioprotective (50% (p <0.05) and 75% (p <0.001), respectively) activity. The results indicate the feasibility of Trymetazidin and Rhythmokor and their combination with Amiodarone in terms of glycoside intoxication. |
| Tags |
glycoside intoxication, cardiac arrhythmia, cardioprotective agents |
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| Publication of the article |
«World of Medicine and Biology» №4(47) 2 part 2014 year, 086-090 pages, index UDK 615.036:615.099 |
