| About the author: |
Yelinska A. M., Kostenko V. O. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The role of NO-synthases and nuclear factor κB (NF-κB) in the mechanisms impairing protein synthesis function of submandibular salivary glands (SSG) under modeled metabolic syndrome (MS) was investigated on 40 white rats. We have found out this function depends on the functional state of NO-synthases. Functioning of neuronal NO-synthase under these conditions increases the activity of α-amylase in SSG tissues. Functioning of inducible NO-synthase in experimental conditions inhibits the activity of α-amylase and ornithine decarboxylase in SSG. Administration of L-arginine during MS modeling did not significantly affect α-amylase activity in the SSG tissues, but limited the decrease in ornithine decarboxylase activity. The introduction of peroxynitrite scavenger L-selenomethionine and NF-κB activation inhibitor JSH-23 under the experimental MS significantly improves protein synthesis in SSG, which is not typical in metformin hydrochloride administration. |
| Tags |
metabolic syndrome, NO-synthases, salivary glands, α-amylase, ornithine decarboxylase |
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| Publication of the article |
«World of Medicine and Biology» №4(47) 2 part 2014 year, 120-123 pages, index UDK 616.316–008–092.18–092.6 |
