| About the author: |
Zhurakivska O. Ya. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Research is devoted to studying morphofunctional organization of median hypothalamus parvocellular nuclei and neurohypophysis median eminence in streptozotocin-induced diabetes mellitus. It was stated that on 14th day of experimental diabetes mellitus in the arcuate and ventromedial hypothalamic nuclei are observed adaptive-compensatory processes in response to hyperglycemia and metabolic changes in the body. These processes are characterized by the growth of neuroendocrine cells functional activity that morphologically is manifested by increase in the area of perikaryons, nuclei and nuclear-cytoplasmic index, increase in volumetric density of neurosecretory granules in neuroplasm. Under these conditions morphofunctional alteration of the outer zone of the neurohypophysis median eminence reflects changes aimed at rapid receipt of neurosecretory substance to the blood. |
| Tags |
diabetes mellitus, arcuate nucleus, ventromedial nucleus |
| Bibliography |
- Zhurakivska O. Ya. Osoblivosti strukturnoyi perebudovi somatotropiv gipofizu na rannih stadiyah rozvytku eksperimentalnogo tsukrovogo diabetu u nestatevozrilih tvaryn / O. Ya. Zhurakivska // Visnyk morfologiyi. – 2012. – T.18, No 1. – S. 104–107.
- ZhurakIvska O. Ya. Osoblivosti ultrastrukturnoyi organizatsiyi kortikotropiv pri eksperimentalnomu tsukrovomu diabeti v postnatalnomu periodi ontogenezu / O. Ya. ZhurakIvska, V. A. Levitskiy // Visnyk Vinnytskogo natsionalnogo medychnogo universitetu. – 2012. – T. 16, No1. – S. 33-36.
- Pat. No 62966. Ukrayina, MPK 51 A 61 V 10/00. Sposib modelyuvannya tsukrovogo diabetu 1-go tipu u tvaryn riznogo viku / V.A. Levitskiy, O.Ya. Zhurakivska, V.A. Miskiv, L.M. Zayats, R.B. Petriv, Yu.M. Yakymiv, B.M. Kischuk, R.Z. Gnatyuk; zayavka No u 201101566; zayavl. 11.02.2011; opubl. 20.09.2011.Pat. No62966.
- Halangot M. D. Deyaki chinnyky ryzyky smertnosti na tsukroviy diabet pershogo tipu v Ukrayini, otsineni za danymy zagalnonatsionalnogo reyestru / M. D. Halangot, M. D. Tronko, V. I. Kravchenko [ta in.] // Endokrinologiya. – 2010. – T.15, No 1. – S. 62–70.
- Borchers A. T. The geoepidemiology of type 1 diabetes / A. T. Borchers, R. Uibo, M. E. Gershwin // Autoimmunity reviews. – 2010. – Vol. 9. – Issue 5. – P. A355– A365.
- Fioramonti X. Characterization of glucosensing neuron subpopulations in the arcuate nucleus: integration in neuropeptide Y and pro-opio melanocortin networks? / X. Fioramonti, S. Contié, Z. Song [et al.] // Diabetes. – 2007. – Vol. 56, № 5. – P. 1219–1227.
- Guven A. Central nervous system complications of diabetes in streptozotocin-induced diabetic rats: a histopathological and immunohistochemical examination / A. Guven, O. Yavuz, M. Cam [et al.] // Int. J. Neurosci. – 2009. – Vol. 119, № 8. – P. 1155–1169.
- Jöhren O. Adrenal expression of orexin receptor subtypes is differentially regulated in experimental streptozotocin induced type-1 diabetes / O. Jöhren, J. A Gremmels, F. Qadri [et al.] // Peptides. – 2006. – Vol. 27, № 11. – P. 2764–2769.
- Ludwiga B. Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets / B. Ludwiga, Ch. G. Zieglera, A. V. Schallyc [et al.] // PNAS. – 2010. – Vol. 107, № 28. – P. 2623–12628.
- Paranjape S. A. Influence of insulin in the ventromedial hypothalamus on pancreatic glucagon secretion in vivo / S. A. Paranjape, O. Chan, W. Zhu [et al.] // Diabetes. –2010. – Vol. 59, № 6. – P. 1521–1527.
- Vanelli M. Effects of intravenous TRH on growth hormone and Cortisol serum levels in children and adolescents with insulin dependent diabetes mellitus / M. Vanelli, S. Bernasconi, O. Bolondi [et al.] // J. Endocrinol. Invest.– 1986. – № 9. – P. 293–297.
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| Publication of the article |
«World of Medicine and Biology» №4(47) 2 part 2014 year, 123-127 pages, index UDK 611.814.1+611.814.3+ 616.379-08.64 |
