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    Kushnaryova E. A.

    THE REGENERATION OF LEYDIG CELLS IN TRANSPLANTATION TESTIS


    About the author: Kushnaryova E. A.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The data of this study allow us to make conclusions about the effectiveness of methods of transplantation and xenotransplantation immature testis, contributing to overcome the reaction of tissue incompatibility and graft rejection. This is due to the fact that in the convoluted seminiferous tubules of immature testis are no spermatocytes of the first order and differentiated germ cells, which are antigenic for both its own body, and for the recipient's body and causing the subsequent reaction of rejection of trasplantants. Transplantation of the testis in an orthotopic position includes maintaining optimal temperatutry and vascularization of transplanted male sexual glands. As a result, achieved recovery and restoration of endocrine cells. We believe that the free transplantation of immature testis can be considered as one of the methods of filling androgen deficiency of the recipient.
    Tags Leydig cells, transplantation, testis
    Bibliography
    • Avtandilov G. G. Meditsinskaya morfometriya: Rukovodstvo / G. G. Avtandilov // M.: Meditsina, - 1990. – 384 s.
    • Artyuhin A. A. Sposob lecheniya bolnyih s narusheniem muzhskoy polovoy funktsii metodom transplantatsii / A. A. Artyuhin, E. I. Zarayskiy, A.I. Romanov // Patent RF RU (11) 2200012 (13) C1 2003.03.10.
    • Bondarenko V. O. Gipoandrogenemiya ta cholovicha neplidnist / V.O. Bondarenko, O.M. Demchenko, T. Yu. Burma [ta in.] // Seksologiya i andrologiya / – K.: In-t urologii i nefrologii AMN Ukrainy, - 2000. – Vyp. 5 – S.112 – 114.
    • Bondarenko T. P. Korrektsiya gormonalnogo statusa u kastrirovannyih i s eksperimentalnyim gipogonadizmom kryis putem allo- i ksenotransplantatsii organotipicheskih kultur / T. P. Bondarenko, S. Abu-Zhayab, G.A. Bozhok [i dr.] // Problemy ekologyii ta meditsiny – 2003 – T.7, No1 – 2. – S.3-7.
    • Vozianov O. F. Klinichna seksologiya i andrologiya / O. F. VozIanova I. I. Gorpinchenko // - K.: Zdorovya, - 1996. - 536 s.
    • Grischenko V. I. Kriobiologiya i problema besplodiya /V.I.Grischenko, Yu.S.Paraschuk, F.V.Dahno [i dr.] //Kiev.:–1990.–136 s.
    • Karpuhin V. T. Eksperimentalnaya implantatsiya yaichka / V.T. Karpuhin // Vopr. urologii. - Zaporozhe, - 1964. -S.57-60.
    • Kirpatovskiy I. D. Hirurgicheskaya korrektsiya endokrinnoy impotentsii / I. D. Kirpatovskiy, D. L. Gorbatyuk // – M.: Universitet druzhby narodov. – 1986. – 170 s.
    • Kirpatovskiy I. D. Razrabotka metodiki subkapsulyarnoy intratestikulyarnoy peresadki gipofiza / I. D. Kirpatovskiy, E. S. Dendeberov // Problemyi reproduktsii. -2000. - No5. - S.75-77.
    • Kirpatovskiy I. D. Podderzhanie gormonalnogo gomeostaza sochetannoy i izolirovannoy allotransplantatsiey, ili vozmozhnost sochetannyih endokrinnyih peresadok po printsipu «tri v odnom» / I.D. Kirpatovskiy // - M., - 2000. - S. 317-318.
    • Kushnarev A. A. Ksenotransplantatsiya yaichka / A. A. Kushnarev // Problemyi kriobiologii – 2005 - T.15, No3. - S. 346-348.
    • Luchitskiy V. E. Androgenodefitsitniy stan u cholovikiv, hvoryh na tsukroviy diabet 2 tipu / V. E. Luchitskiy. // Endokrinologiya. - 2012.- No2.- S. 28-36.
    • Nehvyadovich V. Z. Sravnitelnaya otsenka rezultatov gomotransplantatsii yaichek / V. Z. Nehvyadovich // Transplantatsiya organov i tkaney. - Gorkiy, - 1970.-S.176-177.
    • Petrosyan Zh. L. Morfofunktsionalnyiy analiz allotransplantirovannyih semennikov sobak i krys raznogo vozrasta: Avtoref. dis. kand. med. nauk: In-t morfologii cheloveka AMN SSSR / Zh. L. Petrosyan //-M., - 1978.- 21 s.
    • Raytsina S. S. Znachenie vozrastnyih izmeneniy i izmeneniy, voznikayuschih pod vliyaniem sinestrola v semennike krys, dlya ego prizhivleniya pri gomotransplantatsii / S. S. Raytsina, I. S. Kazakova // Materialyi dokl. 3-y Vsesoyuz. Konf. Po peresadke tkaney i organov. Yerevan, - 1963.-S.428-430.
    • Topka E. G. Sposib transplantatsiyi yayechka / E.G. Topka, O. A. Kushnarov // Pat. 56412 A Ukrayiny, MPK A61V17/00 No2002032248; Zayavl. 21.03.2002; opubl. 15.05.2003. Byul.No5. 2 s.
    • Turchin I. S. Transplantatsiya kultur klityn i tkanyn simyanikiv pri gipogonadizmi / I. S. Turchin, M. D. Tronko, I.V. Komisarenko [ta in.] // Kyiv: “Medekol” MNITs BIO-EKOS, - 1999. - 25 s.
    • Buck A. C. Differentiation of first- and second set grafts of neonatal testis, ovary, intestine and spleen implanted beneath the kidney capsule of adult albino rat hosts / A.C. Buck // Amer.J.Anat. - 1963.- Vol.113, №2. - P.189-213.
    • Bressler R. Differentiaion of peritubular myoid cells of the testis. Effects of intratesticular implantation of newborn mouse testis into normal and hypophisecto-mized adults / R. Bressler, M. H. Ross // Biol. Reprod. -1972.- Vol.6, №1. -P.148-159.
    • Brooks J. R. Endocrinology / J. R. Brooks, G. H. Hill, A. deScoville [et al.] // - 1960. -Vol.66 - 392 p.
    • Kitahara S. Secondary treatment failure without anti-human choriogonic gonadotropin antibody in patient with Kallmann syndrome / S. Kitahara, K. Yoshida, K. Ishizaka [et al.] // Int. J.Urol. -1998. - №5, Vol.4. - P. 398-400.
    • Larkin J. H. Differentiation of first and second-set grafts of embrionic, neonatal and adult testis implanted beneath the kidneycapsule of adult rat hosts / J. H. Larkin // Amer. J.Anat. -1960. - Vol.106. - P.73-82.
    • Parker S. Experience with transdermal testosterone replacement therapy for hypogonadal men / S. Parker, M. Armitage // Clin. Endocrinol. Oxf. -1999. -№1. - 57 p.
    Publication of the article «World of Medicine and Biology» №4(47) 2 part 2014 year, 147-150 pages, index UDK 611.631.3/.44:616.681-007.41]-003.93-02 -089.882-092.9