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    Rikalo N. A., Polinkevich S. G.

    FEATURES NUCLEAR DNA PLOIDY OF HEPATOCYTES IN RATS OF DIFFERENT AGES UNDER CONDITIONS OF CHRONIC TOXIC HEPATITIS


    About the author: Rikalo N. A., Polinkevich S. G.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation Nuclear DNA ploidy was determined by the usage of flow cytometry at the rats of different age groups with chronic toxic hepatitis. Revealed that the group of animals with chronic toxic hepatitis significantly bigger amount of the hepatocytes with polyploid DNA in comparison to the intact animals of similar age. In our opinion, this feature changes of the ratio of hepatocytes nuclei with different ploidy can be explained by the fact that the cells with octaploid and dyoctaploid set of nuclear DNA are a reserve pool, and after termination of the pathogenic factor action re-enter to the cell cycle and become a source of formation of diploid cells because regeneration by proliferation of this type hepatocytes is the main mechanism of mass recovery, the structure and function of the damaged liver.
    Tags ploidy, hepatitis, age characteristics
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    Publication of the article «World of Medicine and Biology» №4(47) 2 part 2014 year, 183-186 pages, index UDK 616.36-002:599.323.4:601.2:575.853