Cherban N. G., Rezunenko U. K., Kucheriavchenko M. A., Nikolaeva O. V.

THE STATE OF IMMUNOBIOLOGICAL REACTIVITY IN ANIMALS IN RESPONSE TO PROLONGED SUBTOXIC EXPOSURE TO LAPROXIDES

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About the author:	Cherban N. G., Rezunenko U. K., Kucheriavchenko M. A., Nikolaeva O. V.
Heading	EXPERIMENTAL MEDICINE
Type of article	Scentific article
Annotation	The research deals with the study of the effect exerted by subtoxic doses of laproxides L-303 and L-500 on allergenic properties as well as on the state of cellular and humoral immunity in experimental animals. Laproxide L-303 testing determined clinical and skin manifestations of sensibilization in animals and their absence when testing L-500. In the dosage of 1/100 and 1/1000 LD50 L-303 inhibits cellular and humoral immunity, DNA, RNA and protein synthesis, induces pro-inflammatory reactions. Laproxide L-500 in the dosage of 1/100 LD50 inhibits cellular and humoral immunity, suppresses DNA, RNA and protein synthesis with underlying activation of pro-tumor cytokines. L-500 in the dosage of 1/100 LD50, L-303 in the dosage of 1/100 and 1/1000 LD50 have been found to condition the development of immunological deficiency and the dysfunction of immunological reactivity.
Tags	xenobiotics, laproxides, sensibilization, immunological deficiency
Bibliography	Zhukov V. I. Detergenty – modulyatory radiomimeticheskih effektov / V. I. Zhukov, V. V. Myasoedov, V. I. Piven [i dr.] // – Belgorod, - 2000. – 376 s. Zhukov V. I. Prostyie i makrotsiklicheskie efiry: Nauchnyie osnovy ohrany vodnyih obyektov / V. I. Zhukov, L. D. Popova, O. V. Zaytseva [i dr.] // – Kharkov, Tornado, - 2000. – 498 s. Zhukov V. I. Ftoridy: biologicheskaya rol i mehanizm deystviya / V. I. Zhukov, O. V. Zaytseva, V. I. Piven [i dr.] // – Belgorod, - 2006. – 220 s. Kratenko R. I. Biologicheskaya aktivnost kraun-efirov v svyazi s problemoy ohrany vodnyih obektov / R. I. Kratenko // – Kharkov, HGMU, - 2001. – 205 s. Scherban N. G. Biohimicheskie mehanizmy radiomimeticheskih effektov poverhnostno-aktivnyih veschestv / N. G. Scherban, V. I. Zhukov, V. V. Myasoedov [i dr.] // – Kharkov, ,,Raritety Ukrainy”, - 2012. – 126 s.
Publication of the article	«World of Medicine and Biology» №4(47) 2 part 2014 year, 206-210 pages, index UDK 612.017.1:616-099-092.9:547.911-311-145.82