English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Shkumat M., Leonov Y., Pishel I.

    EFFECT OF IGF-1 ON WOUND HEALING IN AGED FVB MICE WITH K14SIGF1 TRANSGENES


    About the author: Shkumat M., Leonov Y., Pishel I.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation One of the main factors that can exert influence on the state and the rate of skin regeneration is IGF-1. A morphological studies of wound healing rate was performed in wild-type and transgenic FVB-K14/mIGF-1 mice of different ages to determine the effect of IGF-1 on wound healing in aging. It has been shown that an increase in area and thickness of the regenerating epithelium in the wound of transgenic animals compared with wild-type.
    Tags skin, wound healing, aging, IGF-1
    Bibliography
    • Auf dem Keller U. Reactive oxygen species and their detoxification in healing skin wounds / U. Auf dem Keller, A. Kümin, S. Braun // Journal of Investigative Dermatology Symposium Proceedings.– 2006.– Vol.11.– Р. 106–111.
    • Barreca A. In vitro paracrine regulation of human keratinocyte growth by fibroblast-derived insulin-like growth factors / A. Barreca, M. De Luca, P. Del Monte [et al.] // J. Cell Physiol.– 1992.– Vol.151, No. 1.– Р. 262–268.
    • Blenis J. Signal transduction via the MAP kinases: proceed at your own risk / J. Blenis // Proc. Natl. Acad. Sci. USA.– 1993.– Vol. 90, No. 13.– Р. 5889–5892.
    • Blakytny R. Lack of insulin-like growth factor 1 (IGF1) in the basal keratinocyte layer of diabetic skin and diabetic foot ulcers / R. Blakytny, E. B. Jude, J. Martin-Gibson [et al.] // J. Pathol.– 2000.– Р. 589–594.
    • Cummings D. Growth Hormone Therapy in Adults / D. Cummings, G. Merriam // Annual Review of Medicine.– 2003.– Vol. 54, No. 1.– Р. 513–533.
    • Green H. A dual effector theory of growth-hormone action / H., M. Green, Morikawa, T. A. Nixon // Differentiation.– 1985.– Vol. 29, No. 3.– Р. 195–198.
    • Grazul-Bilska A. Wound healing: The role of growth factors / A. Grazul-Bilska, M. Johnson, J. Bilski [et al.] // Drugs Today.– 2003.– Vol.39, No. 10.– Р. 787–795.
    • Eming S. Targeted expression of insulin-like growth factor to human keratinocytes: modification of the autocrine control of keratinocyte proliferation / S. Eming, R. Snow, M. Yarmush [et al.] // J. Invest. Dermatology.– 1996.– Vol.107, No. 1.– Р. 113–120.
    • Guler H. Recombinant human insulin-like growth factor I stimulates growth and has distinct effects on organ size in hypophysectomized rats / H. Guler J. Zapf, E. Scheiwiller [et al.] // Proc. Natl. Acad. Sci. USA.– 1988.– Vol.85, No. 13.– Р. 4889–4893.
    • Johansson O. Y-melanocyte stimulating hormone (γ-MSH)- like immunoreactivity is present in certain normal human keratinocytes / O. Johansson, O. Peng Yue Liu // Exp. Dermatology.– 1993.– Vol.2, No. 5.– Р. 204–208.
    • Martin P. Wound Healing - Aiming for Perfect Skin Regeneration / P. Martin // Science.– 1997.Vol. 276, No. 5309.Р. 75-81.
    • Philpott M. Effects of insulin and insulin-like growth factors on cultured human hair follicles: IGF-I at physiologic concentrations is an important regulator of hair follicle growth in vitro / M. Philpott, D. Sanders, T. Kealey // J. Invest. Dermatology.– 1994.– Vol.102, No. 6.– Р. 857–861.
    • Rudman S. The Role of IGF-I in Human Skin and its Appendages: Morphogen as Well as Mitogen? / S. Rudman, M. Philpott, G.Thomas [et al.] // J. Invest. Dermatology.– 1997.– Vol.109, No. 6.– Р. 770–777.
    • Semenova E. Overexpression of mIGF-1 in keratinocytes improves wound healing and accelerates hair follicle formation and cycling in mice / E. Semenova, H. Koegel, S. Hasse [et al.] // The American J. Pathology.– 2008.– V.173, No. 5.– Р. 1295–1310
    • Tavakkol A. Expression of Growth Hormone Receptor, Insulin- Like Growth Factor 1 (IGF-1) and IGF-1 Receptor mRNA and Proteins in Human Skin / A. Tavakkol, J. Elder, C. Griffiths [et al.] // J. Invest. Dermatology.– 1992.– Vol.99, No. 3.– Р. 343–349.
    • Wetzler C. Large and sustained induction of chemokines during impaired wound healing in the genetically diabetic mouse: prolonged persistence of neutrophils and macrophages during the late phase of repair / C. Wetzler. H. Kampfer, B. Stallmeyer [et al.] // J. Invest. Dermatol.– 2000.– Vol.115, No. 1.– Р. 245–253.
    Publication of the article «World of Medicine and Biology» №4(47) 2 part 2014 year, 210-213 pages, index UDK 612.79:612.67.014.3