English Українська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    N. V. Gasyuk, G. A. Yeroshenko

    FEATURE OF CELLULAR COMPOSITION OF THE GUMS IN GENERALIZED PERIODONTITIS


    About the author: N. V. Gasyuk, G. A. Yeroshenko
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation An article presents the results of a research of the cellular composition of epithelial and connective tissue fractions of periodontal pockets in patients with chronic generalized periodontitis. It was established that due to prolonged presence of inflammation in the periodontium, a violation of epithelial keratinization occurs, that is characterized by the absence of all epithelial cells and the change in percentage of cell avanguard. Three types of smears were determined, according to a number of hematogenous cells prevalence, that is in comparison with a history of patients, regarding the frequency of exacerbations, made it possible to formulate criteria for prognostic clinical course of generalized periodontitis. The above mentioned, makes it possible to assert that cellular and humoral immunity of periodontal pockets are closely related together, primarily by polymorphonuclear leukocytes and macrophages. These cells play a key role in the inflammatory response and protecting the body from external influence factors including bacteria and their toxins.
    Tags periodon, epitheliocytes, generalized periodontitis, leukocytes
    Bibliography
    • Gasjuk N. V. Іmunogіstohіmіchna harakteristika klіtinnih іnfіl'tratіv vlasnoї plastinki jasen pri parodontitі / N. V. Gasjuk // Medichna hіmіja. – 2014. ─ 16, №3 (60). – S. 78 – 81.
    • Gasjuk P. A. V. Osoblivostі morfologіchnoї budovi jasen v normі і pri hronіchnih gіngіvіtah : Navchal'nij posіbnik dlja studentіv vishhih medichnih navchal'nih zakladіv ІІІ − ІV rіvnіv akreditacії / P. A. Gasjuk, N. V. Gasjuk // ─ Ternopіl': Ukrmedkniga, - 2014. – 92 s.
    • Berglundh T. The presence of local and circulating autoreactive V cells in patients with advanced periodontitis / T. Berglundh, V. Liljenberg, A. Tarkowski [et al.] // J. Clin. Periodontal. – 2002. – Vol. 29, №4. – P. 281-286.
    • Chen J. Porphyromonas gingivalis / J. Chen // Implications of immune evasion // Biol. Chem. J. – 1998. – Vol. 273. – P. 6611–6614.
    • Chatenoud L. Suppressor T cells they're back and critical for regulation of autoimmunity / L. Chatenoud, B. Salomon, J.A. Bluestone // Immunol. Rev. – 2001. – Vol. 182. – P. 149–163.
    • Chen N. J. Enhanced secretion of IFN-gamma by activated Thl cells occurs via reverse signaling through TNF-related activation-induced cytokine / N. J. Chen, M. W. Huang, S. L. Hsieh //J. Immunol. – 2001. – Vol. 166. – P. 270–276.
    • Cao S.L. In vivo induced antigenic determinants of Aetinobacillus actinomycetemcomitans / S. L. Cao, A. Progulske-Fox, J. D. Hillman [et al.] // FEMS Microbiol. Lett. – 2004. – Vol. 237. – P. 97–103.
    • Carayol N. A dominant function of IKK/NF-kappaB signaling in global lipopolysaccharide-induced gene expression / Carayol N., Chen J., Yang F. [et al.] // J. Biol. Chem. – 2006. – Vol. 51. – P. 241–248.
    • Chappie I. L. The prevalence of inflammatory periodontitis is negatively associated with serum antioxidant concentrations / I. L. Chappie, M. R. Milward, T. Dietrich // J. Nutr. - 2007. – Vol. 64. – P. 657–673.
    • Etz H. Identification of in vivo expressed vaccine candidate antigens from Staphylococcus aureus / H. Etz, D. B. Minh, T. Henics [et al.] // Proc. Natl. Acad. Sci. USA. − 2002. −Vol. 99. − P. 6573−6578.
    • Ellis T. N. Interferon-gamma activation of polymorphonuclear neutrophil function / T. N. Ellis, B. L. Beaman // Immunology. − 2004. − Vol. 112. − P. 2−12.
    • Faggion C. M. Prognostic model for tooth survival in patients treated for periodontitis / C.M. Faggion, G. Petersilka, D. E. Lange [et al.] // J. Clin. Periodontal. − 2007. − Vol. 31. − P. 226−343.
    • Herold K. S. Achieving antigen-specific immune regulation / K. S. Herold // J. Clin. Invest. − 2004. − Vol. 113. − P. 346−349.
    • Hart G. T. Quantitative gene expression profiling implicates genes for susceptibility and resistance to alveolar bone loss / G. T. Hart, D. J. Shaffer, S. Akilesh [et al.] // Infect. Immun. − 2004. − Vol. 72. − P. 4471−4479.
    • Hajishengallis G. Intracellular signaling and cytokine induction upon interactions of Porphyromonas gingivalis fimbriae with pattern-recognition receptors / G. Hajishengallis, H. Sojar, R.J. Genco [et al.] // Immunol. Invest. − 2004. − Vol. 33. − P. 157−172.
    • Kachlany S.C. The first representative of a new pilin gene subfamily, is required for non-specific adherence of Actinobacillus actinomycetemcomitans / S.C. Kachlany, P.J. Planet, R. Desalle [et al.] //Mol. Microbio. − 2001. − Vol. 40. − P. 542−554.
    • Kononen E. Population-based study of salivary carriage of periodontal pathogens in adults / E. Kononen, S. Paju, P. J. Pussinen [et al.] // J. Clin. Microbiol.− 2007. − Vol. 45, № 8. − P. 2446−2451.
    • Kornman K. S. Bringing light to the heat: «inflammation and periodontal diseases: a reappraisal» / K.S. Kornman, T.E. Van Dyke // J. Periodontol. − 2008. − Vol. 79, № 8. – R. 1313−1326.
    • Kornman K.S. Mapping the pathogenesis of periodontitis: a new look / K.S. Kornman // J. Periodontol. – 2008. – Vol. 79, № 8. – R. 1560–1568.
    • Kornman K. S. The "innovator's dilemma" for periodontists / K.S. Kornman, D. Clem // J. Periodontol. – 2010. − Vol. 81, № 5. – R. 646−649.
    • Lamster I. B. Analysis of gingival crevicular fluid as applied to the diagnosis of oral and systemic diseases / I. B. Lamster, J. K. Ahlo, N. Y. Ann // Acad. Sci. − 2007. − Vol. 29. − P. 198−216.
    • Niederman R. Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice / R. Niederman, T. Westernoff, C. Lee [et al.] // J. Clin. Periodontal. − 2001. − Vol. 28. − P. 569−575.
    • Nishikubo S. An N-terminal segment of the active component of the bacterial genotoxin cytolethal distending toxin V CDTB directs CDTB into the nucleus / S. Nishikubo, M. Ohara, Y. Ueno [et al.] // J. Biol. Chem. − 2003. − Vol. 278. − P. 50671−50681.
    • Van Dyke T.E. Inflammation and factors that may regulate inflammatory response / T.E. Van Dyke, K.S. Kornman // J. Periodontol. – 2008. – Vol. 79, № 8. – R. 1503−1507.
    Publication of the article «World of Medicine and Biology» №1(48), 2015 year, 017-020 pages, index UDK 616.314.17−02−092