Potyazhenko M.M., Cradle N.A., Sokolyuk N.L., Haymenova G.S., Gajewski S.A.

USE OF THE L-ARGININE IN A COMPLEX OF THERAPY OF PATIENTS WITH CHRONIC KIDNEY DESEASE IN COMBINATION WITH CORONARY HEART DISEASE

---

About the author:	Potyazhenko M.M., Cradle N.A., Sokolyuk N.L., Haymenova G.S., Gajewski S.A.
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	The aim of our study was to estimate the efficiency of L-arginine during the corrections of endothelial dysfunction in patients with chronic kidney disease (CKD) ІІ and ІІІ stages in combination with coronary heart disease (CHD) and influence of the treatment on the level of a daily proteinuria. 25 patients with CKD ІІ and ІІІ stages in a combination with CHD were divided into 2 groups. The first group – 13 patients who received solution L-arginine 4,2% - 100 ml once a day in a complex of basic nephroprotector therapy. The second group – 12 patients who received only nephroprotector therapy. The research demonstrates that addition to basic antihypertensive therapy of sol. L-arginine for intravenous introduction promote function improvement of endothelia functions of vessels for 56,6% and reduction of level of a daily proteinuria by 28,9%.
Tags	chronic kidney desease, chronic heart disease, endothelial dysfunction, L-arginine
Bibliography	Babushkina A. V. L-arginin s tochki zrenija dokazatel'noj mediciny / A. V. Babushkina // Ukr. med. Chasopis. – 2009. – № 6(74). – S. 43–48. Topchij I. I. Soderzhanie cirkulirujushhih kletok jendotelija, VE-kadgerina i stabil'nyh metabolitov oksida azota u bol'nyh HBP i GB v dinamike lechenija s primeneniem L-arginina / I. I. Topchij, A. N. Kirichenko, E. N. Shhenjavskaja [i dr.] // Sіmejna medicina. – 2010. – № 3. – S. 35–39. Drexlcr H. Endothelial dysfunction in human disease / H. Drexlcr, B. Hornig // J. Ìîl. Cell. Cardiol.-2009. -№31. R. 50–60. MacGrcgor M. Chronic kidney disease: evolving strategies for detection and management of impaired renal function / M. MacGrcgor, D. Boag, A. Innes // Q. J. Med. - 2011. – № 99. – R. 365–375. Weiner D. Chronic Kidney Disease as a Risk Factor for Cardiovascular Disease and All-Cause Mortality: A Pooled Analysis of Community-Based Studies / D. Weiner [et al.] // J. Soc. Nephrol. – 2009. – № 15. – R. 1307–1315.
Publication of the article	«World of Medicine and Biology» №1(48), 2015 year, 066-068 pages, index UDK 616.12 – 005.4 + 616.61 – 002.2 – 08