Shepitko K.V.

LOW CARBOHYDRATE SPECIFICITY OF RAT DUODENUM WALL MUCOSA IN ADMINISTRATION OF CRYOPRESERVED PLACENTA AND ACUTE PERITONITIS

---

About the author:	Shepitko K.V.
Heading	EXPERIMENTAL MEDICINE
Type of article	Scentific article
Annotation	Intubation of duodenum mucosa by complex of lectins has established that the HPA galactose-specific lectin evoked the increased expression from 75% to 100% on the 7-14 days of the study, indicating about the activation of secretion production in cells of crypt-villus system. Fucose-specific marker (PFA) is intended to estimate the quality of mucus-producing in goblet cells of villi and crypts of duodenum wall mucosa, whereas mannose-specific marker (LSA) – in the crypt. Change of expression of receptors to WGA and SNA sialo-specific lectins are markers of recovery of protective functions of enterocytes (with brush border and without a border) of duodenum mucosa. Acceleration by 75% of proliferative processes in the crypt-villus system after administration of cryopreserved placenta on the 14 day of the study has been noted. Restoration of Paneth cells’ reaction to WGA lectin by 75% has been also detected in intact group, too, indicating about normalization of antibacterial protection in crypt.
Tags	duodenum, lectins, specificity, cryopreserved placenta
Bibliography	Akopjan V.B. Osnovy vzaimodejstvija ul'trazvuka s biologicheskimi ob#ektami: Ul'trazvuk v medicine, veterinarii i jeksperimental'noj biologii / V.B.Akopjan, Ju.A Ershov. // - M. : MGTU im. N. Je. Baumana, 2005. - 224s. Grishhenko V.I. Transplantacija produktov jembriofetoplacentarnogo kompleksa. Ot ponimanija mehanizma dejstvija k povysheniju jeffektivnosti primenenija /V.I. Grishhenko, A.N. Gol'cev // Zh. Problemy kriobiologii. – 2002, № 1. – S.54-84. Nozdrachev. A.D. Anatomija krysy (Laboratornye zhivotnye) / pod red. A.D. Akademika, E.L. Poljakov //Nozdracheva.- SPb.:Izdatel'stvo "Lan'", 2001.-464 s. Halif. I.L. Vospalitel'nye zabolevanija kishechnika (nespecificheskij jazvennyj kolit i bolezn' Krona): klinika, diagnostika, lechenie / Halif, I.D. Loranskaja//.- M.: Miklosh, 2004.- 88 s. Shepіt'ko V.І. Krіokonservovana placenta vpliv na perebіg eksperemental'nogo sіadadenіtu/ V.І. Shepіt'ko, G.A. Єroshenko, T.M. Jurchenko, І.V. Shepіt'ko// – Poltava: Kopirservis, 2013. -122s. Geboes K. Pathology of inflammatory bowel disease (IBD): variability with time and treatment // Colorectal Dis.- 2001.- Vol. 3.- P. 2-12. Tuomola E. M. Chemical, physical and enzymatic pretreatments of adhesion to human intestinal mucus glycoproteins I E.M. Tuomola, A.C. Ouwehand, S.J. Salminen II Int. J. Food Microbiol. - 2001. - Vol. 60, № 1. - P. 75-81.
Publication of the article	«World of Medicine and Biology» №1(48), 2015 year, 185-190 pages, index UDK 616.342 – 018.7:615.36.001.5