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    Vilkhova I. V.

    MORPHOLOGICAL CHANGES OF NEPHRON TUBULES AS A RESULT OF THE CHRONIC OPIOID EFFECT


    About the author: Vilkhova I. V.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The aim of the experiment was to study morphological changes of proximal convoluted tubules, nephron loops and distal convoluted tubules during the 6-week low doses opioid administration. As a result of 6-week administration of opioid analgesic nalbuphine a number of pathological changes in nephron tubules were discovered. The earliest changes, granular dystrophy, happened in proximal convoluted tubules and nephron loops epithelium granular dystrophy. During the study, alterations of mentioned nephrone parts were progressing and till the end of the experiment were the most expressed. After 42 days signs of granular, hyaline-droplet dystrophy and expressed necrotic changes in proximal convoluted tubules epithelium were revealed. Moderate alteration of nephron loops epitheliocytes were observed, such as signs of granular dystrophy and minor necrotic changes. During the study pathological changes of distal convoluted tubules were not revealed.
    Tags kidney, nephron tubules, nalbuphine
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    Publication of the article «World of Medicine and Biology» №2(49) 1 part 2015 year, 084-087 pages, index UDK 611.611-018-068:615.212.7