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    Fik V. B., Fedechko Y. M., Kryvko Y. Ya.

    ORAL CAVITY DYSBIOSIS UNDER THE DURABLE OPIOID ANALGESIC INFLUENCE IN EXPERIMENT


    About the author: Fik V. B., Fedechko Y. M., Kryvko Y. Ya.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation Experiments were hold on white male rats (20) aged 3,5-7,5 months. Experimental animals had been receiving opioid analgesic, derivative of morphine, once a week during 10 weeks. Bacteriological investigation included taking a culture and microscopic investigation of the smear. Мicrobiological investigations show that changes of bacterial population of the oral cavity which develop under the opioid intoxication can be characterized as dysbiosis. Results of our investigation which indicate the importance of the gram-positive microflora in development of inflammatory process in the oral cavity, in particular, importance of the St. aureus, which has wide range of adaptability characteristics and toxins with necrotic influence.
    Tags oral cavity, opioid, microbiological investigation
    Bibliography
    • Dobrovol's'ka M. K. Stan bіocenozu klіnіchnih zubojasennih kishen' hvorih na generalіzovanij parodontit / M. K. Dobrovol's'ka, V. M. Gelej, N.І. Gelej // Klіnіchna stomatologіja . – 2014, № 2.- S. 17-19
    • Zorina O. A. Vzaimosvjaz' kachestvennogo i kolichestvennogo sostava biocenozov rotovoj polosti i individual'nogo geneticheskogo profilja na fone vospalitel'nyh zabolevanij parodonta: avtoref. dis. na soiskanie nauch. stepeni dokt. med. nauk: spec. 14.01.14 «Stomatologija» / O. A. Zorina // – Moskva, - 2011. – 42 s.
    • Kolchev A. A. Kliniko-laboratornaja harakteristika sostojanija organov i tkanej polosti rta u podrostkov bol'nyh opijnoj narkomaniej: avtoref. dis. na soiskanie nauch. stepeni kand. med. nauk:spec. 14.01.06 «Psihiatrija» / A. A. Kolchev // – Moskva, - 2005. – 21 s.
    • Lebedev D.V. Mikrobiocenozy polosti rta u bol'nyh generalizovannym paradontitom, sposob diagnostiki i korrekcii: avtoref. dis. na soskanie nauch. stepeni kand. med. nauk: spec. 03.02.03 «Mikrobiologija» / D.V. Lebedev // – Moskva, - 2011. – 23 s.
    • Panchenko A. V. Rasprostranennost' i biologicheskie svojstva stafilokokkkov, kolonizirujushhih polost' rta pri kariese i parodontite: avtoref. dis. na soiskanie nauch. stepeni kand. med. nauk: spec. 03.02.03 «Mikrobiologija» / A.V.Panchenko // – Volgograd: - 2011. – 25 s.
    • Patent № 71438 Ukraїna, MPK 2006. 01. Sposіb modeljuvannja povedіnkovih reakcіj v eksperimental'nih tvarin pri hronіchnomu vplivі opіoїdu / Pal'tov Є.V., Fіk V.B., Vіl'hova І.V., Onis'ko R.M., Fіt'kalo O.S., Krivko Ju.Ja.; Zajavnik і patentovlasnik L'vіvs'kij nac. med. un-t іmenі Danila Galic'kogo. – Nomer zajavki u 2012 00427; zajavl. 16.01.2012; opubl. 10.07.2012, Bjul. № 13
    • Patent № 79565 Ukraїna, MPK 2006.01. Sposіb kontrolju za rozvitkom gnіjno-zapal'nih procesіv rotovoї porozhnini na fonі vplivu opіoїdnogo anal'getika v umovah modeljuvannja / Fіk V.B., Fedechko J.M., Krivko Ju.Ja., Pal'tov Є.V., Onis'ko R.M., Fіt'kalo O.S.; Zajavnik і patentovlasnik L'vіvs'kij nac. med. un-t іmenі Danila Galic'kogo. – Nomer zajavki u 2012 12479; zajavl. 01.11.2012;opubl. 25.04.2013; Bjul. № 8
    • Fursa A. A. Osobennosti diagnostiki i lechenija ostryh gnojnyh zabolevanij mjagkih tkanej u bol'nyh s dissocial'nym tipom povedenija: avtoref. diss. na soisk. nauch. stepeni kand. med. nauk: spec. 14.01.17. – “Hirurgija” / A.A. Fursa // - Moskva, - 2011. – 25 s.
    • Aas J. A. Defining the normal bacterial flora of the oral cavity / J.A. Aas, В.J. Paster, L.N. Stokes [et al.] // J.Clin. Microbiol. - 2005. - Vol.43, №11. - P.5721-5732.
    • Botero J. E. Occurrence of periodontopathic and superinfecting bacteria in chronic and aggressive periodontitis subjects in a Colombian population / J.E. Botero, A. Contreras, G. Lafaurie [et al.] // J. Periodontol. - 2007. -Vol.78, №4. - P.696-704.
    • Damir T. Effects of different blood groups on the reproduction of periodontal pocket bacteria / T. Damir, H. Uslu, R. Orbac [et al.] // Int Dent J., - 2009. - Vol. 59, №2. - P. 83-86.
    • Naka S. Distribution of periodontopathic bacterial species in Japanese children with developmental disabilities / S. Naka, A. Yamana, K. Nakano [et al.] // BMC Oral Health. - 2009. -Vol.23, №9. - P.24.
    Publication of the article «World of Medicine and Biology» №2(49) 1 part 2015 year, 141-145 pages, index UDK 616.31-008.87:615.212.7]-092.4/.9