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    Vasylyeva I. M., Krasnoselskey N. V., Zhukov V. I., Vynnik Yu. A.

    STATE OF METABOLIC INDICES IN PATIENTS WITH GASTROCANCEROGENESIS AND THEIR DIAGNOSTIC VALUE


    About the author: Vasylyeva I. M., Krasnoselskey N. V., Zhukov V. I., Vynnik Yu. A.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation According to numerous publications, a steady increase in cancer incidence has been observed in recent years. In many cases it is accompanied by the abnormal clinical course of the disease. Early detection of malignancy and appropriate therapeutic measures are capable to prevent the development of complications of gastrocancerogenesis and prolong 5-year survival of patients. In the world there are many opinions regarding its etiology and pathogenesis. The most common view is scientific hypothesis about the numerous abnormalities of signaling, regulatory and integrative metabolic, cellular systems, providing adequate plastic, energy, proliferative and differentiation processes, whose changes can lead to malignant transformation of cells. The state of monitoring metabolic parameters in serum of patients with gastrocancerogenesis was studied and prognostic criteria of the severity of the disease and effectiveness of pathogenetic treatment were substantiated. This article is devoted to the study of monitoring metabolic indices for assessing impairments of homeostatic functions of the organism in 44 gastric cancer patients aged from 43 to 68 years with different stages of tumor development. Patients with gastrocancerogenesis had elevated levels of AsAT, AlAT, γ-GT, AP, CPK, CPK MB, and LDH in blood serum. The study of monitoring metabolic parameters in patients with gastrocancerogenesis showed reduction in glucose, urea, creatinine, total protein, albumin, cholesterol and elevation of triacylglycerol in plasma. The development of gastrocancerogenesis leads to significant impairments of protein, lipid, carbohydrate and mineral metabolism that are cooperatively linked to dysfunction of various organs and tissues and suppression of bioenergetic processes.
    Tags gastrocancerogenesis, monitoring and metabolic indices, transferases
    Bibliography
    • Zhuntova G. V. Ocenka vlijanija radiacionnyh i neradiacionnyh faktorov na zabolevaemost' rakom zheludka u rabotnikov PO «Majak». Moskva / G.V. Zhuntova // Medicinskaja radiologija i radiologicheskaja bezopasnost'. – 2009. – T. 54, # 2. – S. 38-46.
    • Lifshic V. M. Biohimicheskie analizy v kletke (Spravochnik) / V.M. Lifshi, V.I. Sidel'nikova // – M.: Triada-H, - 2002. – 201s.
    • Moiseenko M. D. Ob oslozhnenijah raka zheludka flegmonoj / M.D. Moiseenko // Vestn. Hir. – 1956. – T. 77, # 5. – S. 62-66.
    • Meshkov N. P. Praktikum pobiohimii / N. P. Meshkov, S. E. Severina // – M.:MGU, - 1979. – 408 s.
    • Popova L. D. Funkcional'naja biohimija pecheni / L. D. Popova, V.V. Davydov, V.I. Zhukov [i dr.] // – Har'kov: Krokus, - 2009. – 114s.
    • Rak v Ukraine, 2009-2010. Zabolevaemost', smertnost', pokazateli dejatel'nosti onkologicheskoj sluzhby. – Bjul. Nacional'nogo kancer-reestra Ukrainy. – K.: - 2011. – #2. – 108 s.
    • Tolpinskij A. P. Oslozhnenie raka zheludka / A. P. Tolpinskij, B. V. Tokarev, I. E. Bahlaev // Metodicheskie ukazanija. – Petrozavodsk. – 1995. – 25 s.
    • Hazanov A. I. Funkcional'nye proby v diagnostike zabolevanij pecheni / A. I. Hazanov // – M.: Medicina. – 1968. – 403s.
    • Hornberg J. J. Cancer: A systems biology disease. / J. J. Hornberg, F. J. Brugemann, H.V. Westerhoff [et al.] // Bio Centrum. – 2005. – P. 1-10.
    • O’Shea J.J. JAKs and STATs in Immunity, Immunodeficiency, and Cancer / J.J. O’Shea, M.M. Holland, L.M. Straud // N Engl J Med. – 2013. - # 368. – P. 161-170.
    Publication of the article «World of Medicine and Biology» №2(50) 2 part 2015 year, 013-017 pages, index UDK 577.12:616.33-006-037