| About the author: |
M. A. Dgebuadze |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Experiments were carried out on 15 mature Chinchila rabbits of both sexes with sepsis caused by staphylococcus aureus. On 9th and10th days after bacterial contamination morphological study of liver and spleen of the rabbits were conducted using histological and morphometric methods. Thrombohemorrhagic disorders of vessels and parenchyma of the liver and spleen were revealed, wich were followed by dystrophic-necrotic changes of parenchyma abovementioned organs. |
| Tags |
experimental sepsis, liver, spleen |
| Bibliography |
- Alekseev S. A. Problema abdominal'nongo sepsisa v hirurgii. Soobshhenie 4: poliorgannaja nedostatochnost' / S. A. Alekseev, Ju. M. Gain, V. G. Bogdan [i dr.] // Belorusskij medicinskij zhurnal. - 2003. - №1.
- Dgebuadze M. A. Kolichestvennaja ocenka dinamiki morfologicheskih izmenenij v gepatocitah pri travmaticheskom shoke / M. A. Dgebuadze, S. B. Stefanov, Z. I. Kacitadze // Tez. dokl. konfer. molodyh uchenyh in - ta jeksperim. morfologii im. A. N. Natishvili AN GSSR. - Tbilisi, - 1984. - S.70-73.
- Daniels R. Surviving the first hours in sepsis: getting the basics right (an intensivist's perspective) / R. Daniels // Antimicrob. Chemother. - 2011. - Vol.66 (suppl. 2). - P.11-23.
- Hutchins N. A. Kupffer Cells Protect Liver Sinusoidal Endothelial Cells from Fas-Dependent Apoptosis in Sepsis by Down-Regulating gp130 / N. A. Hutchins, C. S. Chung, J. N. Borgerding [et al.] // Am. J. Pathol. - 2013. - Vol. 182, N 3. - P. 742-754.
- Watson R. S. The increasing burden of severe sepsis in US children / R. S. Watson, W. T. Linde-Zwirble, J. Lidicker [et al.] // Crit. Care Med. - 2001. –Vol. 29, N 12. - P. A8.
- Weiss Y. G. Compensatory hepatic regeneration after mild, but not fulminant , intraperitoneal sepsis in rats / Y. G. Weiss, L. Bellin, P. K. Kim [et al.] // Am. J. Physiol. - Gastrointestinal and Liver physiology. – 2001. - Vol. 280, №5. - P. 968-973.
- Zeni F. Anti-inflammatory therapies to treat sepsis and septic shock: a reassessment / F. Zeni, B. Freeman, C. Natanson // Crit. Care Med. - 1997. – Vol.25, N7. - P.1095 -1100.
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| Publication of the article |
«World of Medicine and Biology» №2(50) 2 part 2015 year, 118-120 pages, index UDK 616.94-092.4:616.36:616.411 |
