| About the author: |
Denisyuk O. M |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Anticonvulsant activity of new representative activators of K+-channels derivatives N-(-4-diftorometoxyphenil)-N'-1,2,2-trimetylpropyl-N"-cyanoguanidine (flokalin) has been analysed on laboratory rats. As experimental models seizures caused hemokonvulsants (korazol and kordiamin) and maximal electroshock were considered. It has been found that flokalin (1 mg/kg) showed anticonvulsant action that was manifested of significant increase of latent period before convulsions and decrease the duration and severity of convulsions, likely decrease mortality animals compared to the control group. Flocalin slightly inferior to the reference drug carbamazepine (62 mg/kg). These results confirm the need for further comprehensive study of flokalin for creation on its basis of a new domestic cerebroprotective drug with polytropic pharmacological properties. |
| Tags |
acute cerebrovascular blood flow, cramps activators of K+-channels, flokalin, carbamazepine |
| Bibliography |
- Burchinskiy S. G. Neyroprotektoryi novogo pokoleniya v sovremennoy nevrologii: ot farmakologii k farmakoterapii / S. G. Burchinskiy // Ukrayinskiy nevrologichniy zhurnal. – 2011. – No.1. – S.76-82.
- Golovenko M. Ya. Doklinichne vivchennya spetsifichnoyi aktivnosti potentsiynih protisudomnih preparativ: metodichni rekomendatsiyi DFTs MOZ Ukrayiny / M.Ya. Golovenko, L.O. Gromov // – Kyiv., - 2003. – 26 s.
- Denisyuk O. M. Skrining tserebroprotektornoyi aktivnosti v ryadu novih pohidnih guanidinu na modeli gostroyi ishemiyi golovnogo mozku / O.M. Denisyuk, G.I. Stepanyuk // Klinichna ta eksperimentalna patologiya. – 2010. – T.IH, No.4(34). – S. 32-34.
- Denisyuk O.M. porivnyalniy vpliv flokalinu ta meksidolu na perebig bioenergetichnih protsesiv pri gostriy eksperimentalniy ishemiyi golovnogo mozku / O.M. Denisyuk // Bukovinskiy medichniy visnik. – 2011. – No. 1(57). – S.131-134.
- Zozulya I.S. Suchasniy stan problemi diagnostiki, perebigu, likuvannya gostrih porushen mozkovogo krovoobigu v poliklinichnih umovah / I.S. Zozulya, G.I. Lisenko, I.O. Latoha [ta in.] // Ukrayinskiy medichniy chasopis.–2011.–No.6(86).– S.30-39.
- Kostovetskiy O. V. Harakteristika epileptichnih napadiv pri rozvitku ishemichnogo insultu ta zahodi borotbi z nimi / O.V. Kostovetskiy // Ukrayinskiy medichniy chasopis. – 2003. – No.4(36). – S. 94-96.
- Hasanova D. R. Kliniko-funktsionalnyie i neyro vizualizatsionnyie faktoryi, assotsiiruyuschiesya s razvitiem epilepticheskih pripadkov u bolnyih s ostryim insultom / D. R. Hasanova, T. V. Danilova, I. R. Kamalov // Nevrologicheskiy zhurnal. – 2011. – No.2. – S. 14-18.
- Barrese V. Neuronal potassium channel openers in the management of epilepsy: role and potential of retigabine / V. Barrese, F. Miceli, M. V. Soldovieri [et. al.] // - Clin. Pharmacol. – 2010. – №2. – Р. 225-236.
- Bierbower. Augmentation of M-Type (KCNQ) Potassium Channels as a Novel Strategy to Reduce Stroke-Induced Brain Injury / Bierbower, M. Sonya, Choveau [et al.] // J. Neuroscience. – 2015. – Vol. 35 (5) – P. 2101-2111.
- Kobayashi K. K+-channel openers suppress epileptiform activities induced by 4-aminopyridine in cultured rat hippocampal neurons / K. Kobayashi, Y. Nishizawa, K. Sawada [et al.] // J. Pharmacol. Sci. – 2008. – №108(4). – Р.517-528.
- Zhu H. L. Iptakalim protects against hypoxic brain injury through multiple pathways associated with ATP-sensitive potassium channels / H. L. Zhu, W.Q. Luo, H. Wang // Neuroscience. – 2008. – № 157(4). – P. 884–894.
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| Publication of the article |
«World of Medicine and Biology» №3(52) 2 part 2015 year, 087-090 pages, index UDK 616.8-009.24:615.225 |
