| About the author: |
Dzevulska I.V. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Electron microscope examination on 1, 3, 7, 14, 21 and 30 day after 2-3 degrees burn injuries of the skin in area of 21-23% of the body in rats which were injected the first seven days of 0.9% NaCl solution at a dose of 10 ml per kg in the adrenal glands showed that severe termal injury causes reorganization of structural components of adrenal cortex of experimental animals. The nature and degree of electron microscopic changes depends on the term after burn injury. Compensative and adaptive changes in the structures of cortex combined with signs of destructive disorders that lead to the suppression of adrenal endocrine functions. The maximum level of destructive changes in the cells of the stroma and the parenchyma of the adrenal glands at the ultrastructural level seen after 7 days from the beginning of the experiment. In the late stage of toxemia and septiсotoxemia in rats, after which the skin were injected with 0.9% NaCl solution during seven days, even on 30 day of burn injury in the cortex and medulla of the adrenal glands was absent full compensation of destructive changes. |
| Tags |
electron microscopy, adrenal glands, rats, skin burns, 0.9% solution of NaCl |
| Bibliography |
- Grigoreva T.G. Ozhogovaya bolezn // Mezhdunar.med. zhurn. — 2000. — T.6. — No.2. — S. 53-60.
- Povstyanoy N.E. Sostoyanie pomoschi bolnyim s ozhogami i ih posledstviyami v Ukraine // Mezhdunarodnyiy meditsinskiy zhurnal. — 2003. — No.2. — S. 97-101.
- Nácul FE, Jardim A, MacCord F, Penido C, Gomes MV. Hemodynamic instability secondary to adrenal insufficiency in a major burn patient // Burns : Journal of the International Society for Burn Injuries [2002, 28(3):270-272]
- Palmieri TL, Levine S, Schonfeld-Warden N, O'Mara MS, Greenhalgh DG. Hypothalamic-pituitary-adrenal axis response to sustained stress after major burn injury in children // J Burn Care Res. 2006 Sep-Oct;27(5):742-8.
- Kovalchuk O.I. Morfologichni zmini gipofizarno-adrenalovoyi sistemi schuriv pri termichniy travmi / O.I. Kovalchuk, V.G. Cherkasov, I.V. Dzevulska [ta In.] // Ukrayinskiy naukovo-medichniy molodIzhniy zhurnal. – 2015. – No. 1 (86). – 10-16.
- Cherkasov E.V. Ultrastrukturnyie osobennosti krovenosnyih sosudov organov neyroimmunoendokrinnoy sistemyi pri eksperimentalnoy ozhogovoy bolezni u kryis i ee infuzionnoy terapii kombinirovannyimi giperosmolyarnyimi rastvorami / E.V. Cherkasov, O.I. Kovalchuk, I.V. Dzevulska // «Zhurnal Grodnenskogo gosudarstvennogo meditsinskogo universiteta». – 2015. – No.1– S.68 -72
- Gunas I.V. Perebig opikovoyi hvorobi strukturni zmini organiv neyroimunoendokrinnoyi sistemi za umov zastosuvannya vnutrishnovennoyi infuziyi kombinovanih giperosmolyarnih rozchiniv / I.V. Gunas, I E.V. Cherkasov // Ukrayinskiy morfologichniy almanah, 2014. – T. 12.No. 1. – s. 29-35.
- Dzevulskaya I.V. Morfologicheskaya harakteristika gistogematicheskih barerov v organah neyroimmunoendokrinnoy sistemyi pri infuzionnoy terapii ozhogovoy bolezni kombinirovannyimi giperosmolyarnyimi rastvorami /I.V. Dzevulskaya, Gunas I.V., Cherkasov E.V. [ta in.] // Hirurgiya. Vostochnaya Evropa. –2014. – No. 2 (10). – S. 113-124.
- Kovalchuk O.I. Mehanizmi strukturnoyi transformatsiyi gistogematichnih bar’eriv organiv neyroimunoendokrinnoyi sistemi za umov infuzionnoyi terapiyi opikovoyi hvorobi / O.I., Kovalchuk, I.V Dzevulska, E.V. Cherkasov // Klinichna anatomiya ta operativna hirurgiya. 2014, Tom 13, No. 2, s.69-74.
- Gunas I.V. Dinamika riznih tipiv klitinnoyi smerti v timusi, nadnirkovih zalozah, adenogipofizi ta zmini rivnya endogennoyi intoksikatsiyi vorganizmi schuriv pri eksperimentalniy opikoviy hvorobi za umov infuziyi kombinovanih giperosmolyarnih rozchiniv / I.V. Gunas. V. G.Cherkasov, I.V. Dzevulska [ta in.] // Ukrayinskiy naukovo-medichniy molodIzhniy zhurnal. – 2012. – No. 4. – S. 10-13.
- Dzevulska I.V. Strukturno-funktsionalni zmini kori nadnirkovoyi zalozi pri opikoviy travmi v eksperimenti / I.V. Dzevulska // «Visnik NMU». 2013, No. 4 . – S. 13-21.
- Pshukova A.A. Stroenie stromyi nadpochechnika v norme i patologii. V kn.: Dostizheniya meditsinskoy nauki prakticheskomu zdravoohraneniyu / A.A. Pshukova, A.H. Urusbambetov. – Nalchik, 2007. – S. 108-109.
- Bornstein S.R. Morphological and functional studies of the paracrine interaction between cortex and medulla in adrenal gland / S.R. Bornstein, M.С. Bornstein, W.A. Scherbaum // Microscopy research and technique. – 1997. – Vol. 36. – P. 520-533.
- Cherkasov V.G. Strukturnyie mehanizmyi tsitoprotektsii vo vnutrennih organah pri infuzionnoy terapii ozhogovoy bolezni / V.G. Cherkasov, O.I. Kovalchuk, I.V. Dzevulska [ta in.] // Biomedical and biosocial anthropology.– 2014.– No.23 – S. 6-12.
- Kovalchuk O.I. Vliyanie kombinirovannyih giperosmolyarnyih rastvorov na nanoprotsessyi v stenke krovenosnyih kapillyarov i v interstitsialnom matrikse vnutrennih organov pri ozhogovoy bolezni / O.I. Kovalchuk, E.V. Cherkasov, I.V. Dzevulska [ta In.] // Ukrayinskiy naukovo-medichniy molodIzhniy zhurnal. – 2014, Spetsvipusk No.2 (81). – S.5-10.
- Cherkasov V. G. Strukturnyie osobennosti adaptatsii i kompensatsii narushennyih funktsiy vnutrennih organov pri infuzionnoy terapii ozhogovoy bolezni / V. G. Cherkasov, O.I. Kovalchuk, I.V. Dzevulska // SvIt meditsini ta bIologIYi. – 2014, No.4(46) . – S.165-170.
- Regas F.C. Elucidating the vascular response to burns with a new rat model / F.C. Regas, H.P. Ehrlich // J. Trauma.– 1992.– Vol. 32, № 5.– P. 557-563.
- Stefanov O.V. Doklinichni doslidzhennya likarskih zasobiv. Metodichni rekomendatsiyi / red. O.V. Stefanov. – Kyiv: Avitsena, 2001. – 528 s.
- Gunas I. Method of thermal burn trauma correction by means of cryoinfluence / I. Gunas, I. Dovgan, O. Masur // Verhandlungen der Anatomischen Gesellschaft. 92. In Olsztyn vom 24. Bis 27. Mai 1997: bipartitemeeting / zusammen mit der Polish Anatomical Society with the participation of the Association des Anatomistes. – 1997. – P. 105.
|
| Publication of the article |
«World of Medicine and Biology» №3(52) 2 part 2015 year, 091-098 pages, index UDK 611.453 :611-018]:616-001.17-092.4- 08 |
