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    Mehdiyeva Z. , Gasimov E. , Rzakulieva L. , Rzayev F.


    About the author: Mehdiyeva Z. , Gasimov E. , Rzakulieva L. , Rzayev F.
    Type of article Scentific article
    Annotation 93 of surveyed pregnant women aged 19 to 37 years; of these, in 43 cases diagnosed with the syndrome of delayed fetal growth (sdfd). Studied the cellular and non-cellular structures of Mature intermediate and terminal villi. Electron microscopic study of placentas with intrauterine delay of the fetus showed that in the intervillous lacuna identified tubercles, resembling apoptotic vesicles. Revealed the signs of violation of the integrity of syncytiotrophoblast (STSTB) is not characteristic of apoptosis and necrosis. The close adhesion of villi to each other occurring destructive changes in the cells involved in trophoblastic lining of the villi and in the construction of the walls of the internal vessels, and the extracellular elements, and entering the maternal blood pieces STSTB mostly necrotic origin, caused in utero pathological condition of the mother along with prenatal growth retardation, including contributing to the development of preeclampsia, all these reasons can be assessed as morphological manifestations.
    Tags light and electron microscopic study, placenta, pre-eclampsia, apoptosis
    • Kolesnikov L. L. Terminalogia Embryologica. Mezhdunarodnye terminy po jembriologii cheloveka s oficial'nym spiskom russkih jekvivalentov / L.L. Kolesnikov // M.: GJeOTAR-Media, - 2014, 417 s.
    • Burton G. J. Syncytial knots, sprouts, apoptosis, and trophoblast deportation from the human placenta./ G.J. Burton, C.J. Jones. // Taiwan J Obstet Gynecol. – 2009, Vol. 48(1), R. 28-37.
    • Castellucci M. The development of the human placental villous tree./ M. Castellucci, M. Scheper, I. Scheffen [et al.] // Anat Embryol (Berl). - 1990, Vol. 181(2), R. 117-128.
    • Castellucci M. Villous sprouting: fundamental mechanisms of human placental development. / M.Castellucci, G.Kosanke, V.Verdenelli, et.al // Hum Reprod Update. – 2000, Vol. 6(5), R. 485-94.
    • Coleman S. J. Syncytial nuclear aggregates in normal placenta show increased nuclear condensation, but apoptosis and cytoskeletal redistribution are uncommon / S.J. Coleman, L. Gerza, C.J. Jones, [et al] // Placenta. – 2013, Vol. 34(5), R. 449-55.
    • Eiland E. Preeclampsia / E. Eiland, C. Nzerue, M. Faulkner // J Pregnancy. – 2012, R. 586-578.
    • Əliyarbəyova A. Ə. Ağ siçovullarin onurğa beyni qanqlionunda neyroqlial əlaqələrin mikroskopik və ultrastruktur xüsusiyyətləri / A. Ə. Əliyarbəyova, E.K. Qasımov // Azərbaycan Tibb Jurnalı. Bakı. - 2014, №2, R. 32-39.
    • Fogarty N.M. Syncytial knots (Tenney-Parker changes) in the human placenta: evidence of loss of transcriptional activity and oxidative damage./ N.M. Fogarty, A.C. Ferguson-Smith, G.J. Burton // Am J Pathol. - 2013 Vol. 183(1), R.144-152.
    • George E.M. Endothelin: key mediator of hypertension in preeclampsia / E.M. George, J.P. Granger // Am J Hypertens. – 2011, Vol. 24(9), R. 964-969.
    • Hamilton W. J. Specializations of the syncytium of the human chorion / W.J. Hamilton, J.D. Boyd // Br Med J. – 1966, Vol. 18,1, R. 1501-1506.
    • Huppertz B. Apoptosis in the trophoblast--role of apoptosis in placental morphogenesis / B.Huppertz, J.C. Kingdom // J Soc Gynecol Investig. - 2004, Vol. 11(6), R. 353-62.
    • Huppertz B. IFPA Award in Placentology Lecture: Biology of the placental syncytiotrophoblast--myths and facts / B.Huppertz // Placenta. – 2010, Vol. 31, R.75-81.
    • Ishikawa H. Mitosis and intermediate-sized filaments in developing skeletal muscle / H. Ishikawa, R. Bischoff, H. Holtzer // - J. Cell Biol. - 1968. Vol. 38, 538 r.
    • Jones C.J. Ultrastructure of the normal human placenta./ C.J. Jones, H. Fox // Electron Microsc Rev. – 1991, Vol. 4(1), R. 129-178.
    • Karikoski R. Importance of histopathological examination of the placenta. /R. Karikoski // Duodecim. - 2011, Vol. 127(5), R.464-72.
    • Levy R. To be, or not to be, that is the question. Apoptosis in human trophoblast / R.Levy, D.M. Nelson // Placenta. – 2000, Vol. 21(1), R.1-13.
    • Loukeris K. Syncytial knots as a reflection of placental maturity: reference values for 20 to 40 weeks' gestational age. / K.Loukeris, R.Sela, R.N. Baergen // Pediatr Dev Pathol. – 2010, Vol.13(4), R. 305-309.
    • Longtine M.S. Caspase-mediated apoptosis of trophoblasts in term human placental villi is restricted to cytotrophoblasts and absent from the multinucleated syncytiotrophoblast / M.S. Longtine, B. Chen, A.O. Odibo [et al.] // Reproduction. -2012, Vol.143(1), R.107-121.
    • Mustafa R. A comprehensive review of hypertension in pregnancy./ R. Mustafa, S. Ahmed, A. Gupta [et al.] // J Pregnancy. - 2012, 105918 r.
    • Redman C.W. Latest advances in understanding preeclampsia / C.W. Redman, I. L. Sargent // Science. 2005, Vol. 308 (5728), 1592-1594.
    • Sharp A.N., Heazell AE, Crocker IP, Mor G. Placental apoptosis in health and disease./ A.N.Sharp, A.E.Heazell, I.P.Crocker, G. Mor // Am J Reprod Immunol. – 2010, Vol.64(3), R.159-169.
    • Tomas S. Z. Trophoblast apoptosis in placentas from pregnancies complicated by preeclampsia / S. Z. Tomas, I.K. Prusac, D. Roje [et al.] // Gynecol Obstet Invest. -2011, Vol. 71(4), P.250-255.
    • World Health Organisation, WHO Recommendations for prevention and treatment of pre-eclampsia and eclampsia, Geneva WHO, -2011.
    Publication of the article «World of Medicine and Biology» №4(53) 1 part 2015 year, 045-051 pages, index UDK 616-053