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    Rikalo N. A., Yarovenko L. А.

    ROLE OF INSULIN-LIKE GROWTH FACTOR-1 IN PATHOGENESIS OF CHRONIC ALCOHOLIC LIVER DISEASE IN RATS OF DIFFERENT AGE GROUPS


    About the author: Rikalo N. A., Yarovenko L. А.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation During last ten years, chronic diffuse liver disease due to high morbidity and life-threatening consequences related to the actual problems of modern medicine. The actual topic is to study molecular mechanisms of reparative regeneration of pathological-altered liver and drugs influence on this process. The perspective is the studying of insulin-growth factor-1 (IGF-1) in rats of different age groups with chronic alcohol liver disease and under condition of pharmacocorrection using L-arginine-L-glutamate and quercetin, and study the correlation between IGF-1 and changes of biochemical markers of blood serum. Has been proved that chronic alcohol liver disease decreases the concentration of IGF-1 in the animals of all age groups, which correlates with biochemical markers of cytolysis and cholestasis syndromes. Established that under condition of pharmacocorrection using L-arginine-L-glutamate significantly increases the level of IGF-1, and available direct significant correlation with parameters of functional liver state, indicating restoration of liver parenchyma and its functional state by activation of reparative regeneration. Gained data shows that hepatoprotector L-arginine-L-glutamate has a potitive influence on the regenerative reparation process compared with quercetin.
    Tags age features, chronic alcohol liver disease, insulin-like growth factor-1, biochemical parameters
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    Publication of the article «World of Medicine and Biology» №4(53) 1 part 2015 year, 129-135 pages, index UDK 577.17:591.436:599.323.4