| About the author: |
Bisyuk Yu.A. |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The study included 331 patients with asthma. 4 or more exacerbations during the last year were considered a criterion for frequent asthma phenotype and 3 or less with infrequent exacerbations. Results of the study found that patients with frequent exacerbations characterized by the prevalence of female which were taking combination of inhaled corticosteroids and long-acting β2 agonists and the presence of severe bronchial obstruction in association with high levels of sCD14 in induced sputum. |
| Tags |
bronchial asthma, endotoxin, immunity |
| Bibliography |
- Berezhnaja N. M. Semejstvo interlejkinov 17 / N. M. Berezhnaja, R. I. Sepiashvili // Allergologija i immunologija. - 2015. - Tom. 16, №. 1. - S. 154–164.
- Gordienko A. І., Bіloglazov V. O. Patent 70193 A Ukraїna MKІ 7 A61K31/01 Sposіb viznachennja antitіl do lіpolіsaharidіv gram negativnih bakterіj; Zavl. 29.12.2003; Opubl. 15.09.2004, Bjul. № 9.
- Gordienko A. I. Ispol'zovanie tverdofaznogo immunofermentnogo analiza dlja opredelenija obshhego i antijendotoksinovogo sekretornogo iga cheloveka / A. I. Gordienko // Tavricheskij mediko-biologicheskij vestnik. - 2009. - Tom. 12, No. 3. - P. 82–89.
- Alexis N. CD14-dependent airway neutrophil response to inhaled LPS: role of atopy / N. Alexis, M. Eldridge, W. Reed [et al.] // Journal of allergy and clinical immunology. - 2001. - Vol. 107, No. 1. - P. 31–35.
- Alexis N. E. Effect of inhaled endotoxin on airway and circulating inflammatory cell phagocytosis and CD11B expression in atopic asthmatic subjects / N. E. Alexis, M. W. Eldridge, D. B. Peden // Journal of allergy and clinical immunology. - 2003. - Vol. 112, No. 2. - P. 353–361.
- Cândida Rizzo M. Endotoxin exposure and symptoms in asthmatic children / M. Cândida Rizzo, C. K. Naspitz, E. Fernández-Caldas [et al.] // Pediatric allergy and immunology. - 1997. - Vol. 8, No. 3. - P. 121–126.
- Custovic A. EAACI position statement on asthma exacerbations and severe asthma / A. Custovic, S. L. Johnston, I. Pavord [et al.] // Allergy. - 2013. - Vol. 68, No. 12. - P. 1520–1531.
- Eisenbarth S. C. Lipopolysaccharide-enhanced, Toll-like receptor 4–dependent T helper cell type 2 responses to inhaled antigen / S. C. Eisenbarth, D. A. Piggott, J. W. Huleatt [et al.] // The Journal of experimental medicine. - 2002. - Vol. 196, No. 12. - P. 1645–1651.
- Haldar P. Cluster analysis and clinical asthma phenotypes / P. Haldar, I. D. Pavord, D. E. Shaw [et al.] // American journal of respiratory and critical care medicine. - 2008. - Vol. 178, No. 3. - P. 218–224.
- Hasegawa K. Prevalence of eosinophilia in hospitalized patients with asthma exacerbation / K. Hasegawa, S. J. Stoll, J. Ahn [et al.] // Respiratory medicine. - 2015. – Vol. 111 – P.325-333.
- Lambrecht B. N. The immunology of asthma / B. N. Lambrecht, H. Hammad // Nature immunology. - 2015. - Vol. 16, No. 1. - P. 45–56.
- Michel O. Severity of asthma is related to endotoxin in house dust. / O. Michel, J. Kips, J. Duchateau [et al.] // American journal of respiratory and critical care medicine. - 1996. - Vol. 154, No. 6. - P. 1641–1646.
- Moore W. C. Identification of asthma phenotypes using cluster analysis in the severe asthma research program / W. C. Moore, D. A. Meyers, S. E. Wenzel [et al.] // American journal of respiratory and critical care medicine. - 2010. - Vol. 181, No. 4. - P. 315–323.
- Nadel J. A. Role of neutrophil elastase in hypersecretion during COPD exacerbations, and proposed therapies / J. A. Nadel // CHEST Journal. - 2000. - Vol. 117, No. 5, Suppl 2. - P. 386S–389S.
- Peden D. B. Eosinophil influx to the nasal airway after local, low-level LPS challenge in humans / D. B. Peden, K. Tucker, P. Murphy [et al.] // Journal of allergy and clinical immunology. - 1999. - Vol. 104, No. 2. - P. 388–394.
- Qiu Y. Bronchial mucosal inflammation and upregulation of cxc chemoattractants and receptors in severe exacerbations of asthma / Y. Qiu, J. Zhu, V. Bandi [et al.] // Thorax. - 2007. - Vol. 62, No. 6. - P. 475–482.
- Siwiec J. Evaluation of th1/th2 lymphocyte balance and lipopolysaccharide receptor expression in asthma patients / J. Siwiec, T. Zaborowski, O. Jankowska [et al.] // Pneumonologia I Alergologia Polska. - 2009. - Vol. 77, No. 2. - P. 123–130.
- Sheehan W. J. School endotoxin exposure is associated with increased asthma morbidity / W. J. Sheehan, C. R. Petty, B. Coull [et al.] // Am J Respir Crit Care Med. - 2014. - Vol. 189. - 2288 p.
- Viksman M. Y. Expression of activation markers on alveolar macrophages in allergic asthmatics after endobronchial or whole-lung allergen challenge / M. Y. Viksman, B. S. Bochner, R. S. Peebles [et al.] // Clinical Immunology. - 2002. - Vol. 104, No. 1. - P. 77–85.
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| Publication of the article |
«World of Medicine and Biology» №4(54) 2 part 2015 year, 008-011 pages, index UDK 616.248-07-478.75 |
