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    Asadovа S. I.

    DYNAMICS OF CONCENTRATION OF NEUROSPECIFIC PROTEINS IN THE BLOOD OF PREMATURE INFANTS WITH RESPIRATORY DISTRESS SYNDROME ON THE BACKGROUND OF COMPLEX THERAPY


    About the author: Asadovа S. I.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation 90 premature newborns with SDR have been examined. The children were admitted to the ICU for the first 24-72 hours of life. Depending on the gestational age newborns were divided into 3 groups: I group - 30 infants aged 28-30 weeks. of gestation; group II - 30 newborns at the age of 31-33 weeks. of gestation, and group III - 30 infants 34-36 weeks. of gestation. The level of NSE in the blood of newborns with RDS and CNS was higher than that of newborns with RDS without CNS by 25.6%, and GFK - 54,0% (p<0.05). Comparative analysis showed that the concentration of NSE and GFK in the blood of newborns at the age of 31-33 weeks was higher than the 14.6% and 23.1%, respectively, in infants 34-36 weeks - by 8.7% and 11.9% respectively. The highest NSE 61,0±10,22 ng/ml were observed in newborns of the main group with the syndrome of excitation and relatively low (44,6±9,19 ng/ml) in newborns with the syndrome of depression. The difference in concentration GFCP in the examinees depending on the neurological syndrome was not detected. Nasal CPAP therapy with the early introduction of Curosurf reduced the concentration of NSE in the blood by 26.6%, and GPCP - by 32.9% (p<0.05), and nasal CPAP therapy with the late introduction of Curosurf - 25.9% and 25.1%, respectively. At the same time in neonates who received mechanical ventilation with Curosurf the level of NSE in the blood decreased by 27.2%, the level GFK - 25.3% and in neonates, are connected to the mechanical ventilation without surfactant, the average concentrations of NSE and GFK decreased respectively by 23.6% and 25.7%.
    Tags premature newborn, respiratory distress syndrome, surfactant
    Bibliography
    • Degtyareva M. V. Obzor osnovnyih polozheniy Evropeyskogo konsensusa po taktike vedeniya respiratornogo distress-sindroma u nedonoshennyih novorozhdennyih detey. Peresmotr 2010 goda / M.V. Degtyareva, V.A. Grebennikov, N.N. Volodin // Voprosyi prakticheskoy pediatrii, - 2011, No.3, S.103-110.
    • Zayachnikova T. E. Sovremennyie podhodyi k diagnostike patologicheskih sostoyaniy u nedonoshennyih novorozhdennyih / T.E. Zayachnikova, B.B. Ledenev, I.N. Burzak [i dr.] // Vestn. Volgogradskogo Gos. Med. Universiteta, - 2010, Vyip.2 (34), S. 21-24.
    • Novopoltseva E. G. Neyrospetsificheskaya enolaza v diagnostike perinatalnyih porazheniy tsentralnoy nervnoy sistemyi u nedonoshennyih detey / E. G. Novopoltseva, V. A. Vorobeva, O. B. Ovsyannikova // Pediatricheskaya farmakologiya, - 2010, Tom 7, No.3, S.66-70.
    • Prahov A. B. Vnutriserdechnoe krovoobraschenie u nedonoshennyih novorozhdennyih detey s tyazhelyim perinatalnyim porazheniem TsNS i sindromom dyihatelnyih rasstroystv / A.B. Prahov, L. E. Egorskaya // Pediatriya, - 2008, No.1, S.28-31.
    • Aguar M. Minimally Invasive Surfactant Therapy: An Update./ M. Aguar, M. Vento, P.A. Dargaville // Neoreviews, - 2014, Vol.15, No7, P. 275- 285.
    • Chotigeat U. Comparison outcomes of surfactant therapy in respiratory distress syndrome in two periods / U. Chotigeat, N. Promwong, W. Kanjanapattanakul [et al.] // J. Med. Assoc. Thai., - 2008, № 91(3), Р.109-114.
    • Committee on Obstetric Practice, American College of Obstetricians and Gynecologists: Committee Opinion No. 543. Timing of umbilical cord clamping after birth // Obstet Gynecol, - 2012, Vol.120, P.1522–1526.
    • Rautava L. Perfect Preterm Infant Study Group: 5-year morbidity among very preterm infants in relation to level of hospital care./ L. Rautava, J. Eskelinen, U. Häkkinen [et al.] // Arch Pediatr Adolesc Med., - 2013, Vol.167, P.40-46.
    • Sweet D. G. European Consensus Guidelines on the Management of Neonatal Respiratory Distress Syndrome in Preterm Infants - 2013 Update./ D.G. Sweet, V. Carnielli, G. Greisen [et al.] // Neonatology, - 2013, №103, P. 353-368.
    • Tzialla C. Use and misuse of antibiotics in the neonatal intensive care unit./ C. Tzialla, A. Borghesi, G.F. Perotti [et al.] // J. Matern. Fetal Neonatal Med., - 2012, Vol.25 (suppl 4), P. 35–37.
    Publication of the article «World of Medicine and Biology» №1(55), 2016 year, 017-022 pages, index UDK 616.24-008.4-053.32