| About the author: |
Gorbacheva S.V., Belenichev I.F., Kucherenko L.I., Bukhtiyarova N.V. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Аn important factor in normalization of mitochondrial functioning processes is a maintenance of thiol cellular redox status. Positive influence of thiol-disulfide system modulators explains the fact of their antioxidant action, namely the limitation of negative action of active oxygen forms on mitochondria. Presence of preparations of SH-groups in a molecule structure and their ability to bind cytotoxic derivatives in conditions of oxidative stress protect protein structures of a cell and transcription factors from the oxidative modification. Besides, these factors maintain redox homeostasis that prevents mitochondrial pore opening and formation of mitochondrial dysfunction. |
| Tags |
energetic metabolism, mitochondrial dysfunction, thiol-disulfide system modulators |
| Bibliography |
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| Publication of the article |
«World of Medicine and Biology» №1(55), 2016 year, 122-125 pages, index UDK 616.831-005.1-06:616-008.27.014.425]-092.4 |
