Sithinska I. O.

SOME PATHOGENETIC FEATURES A COMBINATION OF PEPTIC ULCER OF STOMACH AND DUODENUM, ASSOCIATED WITH ARTERIAL HYPERTENSION AND DIABETES MELLITUS TYPE 2

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About the author:	Sithinska I. O.
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	The article is devoted to the study of functional state of endothelium in patients with peptic ulcer of stomach and duodenal ulcers in combination with arterial hypertension and diabetes mellitus type 2. We examined 80 patients (40 patients with peptic ulcer of stomach and duodenal ulcers, 40 patients with peptic ulcer of stomach and duodenal ulcers in combination with arterial hypertension and diabetes mellitus type 2). The disturbance of lipid metabolism and redox systems, which indicates a depletion of the reserves of antioxidant defenses, disorders of the vascular wall, accompanying the strengthening of destructive processes and increased severity of disease.
Tags	peptic ulcer, duodenum, diabetes mellitus type 2, arterial hypertension, lipid metabolism, oxidation-reduction system
Bibliography	Fedorova Z.D., Bessmeltsev S.S., Kotovschikova M.A. Metodyi issledovaniya agregatsii, vyazkosti i deformiruemosti eritrotsitov:. metod. Rekomendatsii / Z. D. Fedorova, S. S. Bessmeltsev, M. A. Kotovschikova // - Leningrad: NII gematologii i perelivaniya krovi. 1989. - 13s. Boehme M. Prevalence of silent gastric ucler, erosions of Severe acute gastritis in patients with type 2 diabetes mellitus: A cross sectional study / M. Boehme, F. Autschbach, C. Ell // Hepatogastroenterol. J. – 2007. – Vol. 54, № 74. – P. 643-648. Coleman J. D. The oxidative stress mediator 4 hydroxynonenal is an intracellular agonist of the nuclear receptor peroxisome proliferator activated receptor β/δ (PPAR  β/δ) / J.D. Coleman, K.S. Prabhu, J.T. Thompson // Free Radic. Biol. Med.- 2007. - Vol. 42. - P. 1155 - 1164. Guzy R.D. Oxygen sensing by mitochondria at complex III: The paradox of increased ROS during hypoxia / R.D. Guzy, P.T. Schumacker // Exp Physiol. - 2006. - Vol. 91, N 5. - P. 807 - 819. Markovic J. Glutathione is recruited into the nucleus in early phases of cell proliferation / J. Markovic, C. Borr´as, A. Ortega // J. Biol. Chem. - 2007. - Vol. 282. - P. 202 - 204.
Publication of the article	«World of Medicine and Biology» №2(56), 2016 year, 080-082 pages, index UDK 616.33+616.342]-002.44-036.1-092:616.12-008.331.1:616.379-008.64