| About the author: |
Maximova I. G. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The activity of enzymes in a microsomal fraction of rat liver on the 30th day of the effects of industrial chemical pollutants - imidazoline mixtures at doses of 1/10 and 1/100 DL50 was determined with the help of spectrophotometric method, which was necessary for the complete explanation of the biochemical mechanisms of their membrane-tropic action. Imidazoline-containing mixtures with alkyl radicals C7-9 and C9-15 at a dose of 1/10 DL50 cause inactivation of microsomal NADPH reductase system, proven by reduced activity of NADPH-cytochrome c reductase and decrease in cytochrome P-450 level. On the contrary, prolonged exposure of mixtures at a dose of 1/100 DL50 leads to its activation, as evidenced by increased activity of NADPH-cytochrome c reductase and level of cytochrome P-450. The revealed changes can be considered as one of the pathogenetic links of biochemical mechanisms of the membrane-tropic action of imidazoline mixtures that need to be taken into account in the development of methods for their correction. |
| Tags |
mixtures of imidazolines, rats, microsomes, NADPH reductase, cytochrome P-450 |
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| Publication of the article |
«World of Medicine and Biology» №2(56), 2016 year, 129-132 pages, index UDK 577.152.1:616.36-092.9-099:543.395 |
