EnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Lymanets T. V., Maslova G. S., Skrypnyk I. M.

    THE NITRIC OXIDE SYSTEM IMBALANCE ROLE IN THE DEVELOPMENT OF ANTHRACYCLINE CARDIOTOXICITY IN ACUTE LEUKEMIA PATIENTS WITH CONCOMITANT ISCHEMIC HEART DISEASE


    About the author: Lymanets T. V., Maslova G. S., Skrypnyk I. M.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation The article presents the own researches results of the leading pathogenetic ways determining of anthracycline-induced cardiotoxicity formation in patients with acute leukemia, depending on the presence of concomitant ischemic heart disease (IHD). The activation of aggressive oxygen species production is observed in all patients at the onset of acute leukemia with simultaneous antioxidant protection exhaustion. These processes are enhanced in the chemotherapy dynamics. In addition, there is an increased activity of summary NO-synthase in all patients with acute leukemia, that only in case of concomitant IHD is accompanied with the development of endothelial dysfunction, which creates conditions for deepening violations in the system of nitric oxide and consequently leads to heart tissue injury on a background of anthracycline antibiotics accumulation.
    Tags acute leukemia, ischemic heart disease, anthracycline cardiotoxicity, nitric oxide, endothelial dysfunction
    Bibliography
    • Berkalo L. V. Metodi klinichnih ta eksperimentalnih doslidzhen v meditsini / L.V. Berkalo, O.V. Bobovich, N.O. Bobrova [ta in.] // Pid red. I.P. Kaydasheva. – Poltava: Polimet, - 2003. – 320 s.
    • Besedina A. S. Vikovi osoblivosti stanu sistemi L-arginin-oksidu azotu u patsientiv z ishemichnoyu hvoroboyu sertsya / A. S. Besedina // Visnik problem biologiyi i meditsini. – 2013. – Vip.2, T. 2. – S. 71 – 76.
    • Stalnaya I. D. Metod opredeleniya malonovogo dialdegida s pomoschyu tiobarbiturovoy kislotyi / I. D. Stalnaya, T. G. Garishvili / – M.: Meditsina, - 1977. – S. 66 – 68.
    • Aldieri E. Doxorubicin induces an increase of nitric oxide synthesis in rat cardiac cells that is inhibited by iron supplementation / E. Aldieri, L. Bergandi, C. Riganti [et al.] // Toxicol. Appl. Pharmacol. – 2002. – Vol. 185. – P. 85–90.
    • Fogli S. The role of nitric oxide in anthracycline toxicity and prospects for pharmacologic prevention of cardiac damage / S. Fogli, P. Nieri, M.C. Breschi // FASEB J. – 2004. – Vol. 18. – P. 664–675.
    • Hevel J.M. Purification of the inducible murine macrophage nitric oxide synthase / J.M. Hevel // J. Biol. Chem. – 1991. – Vol. 266, N34. – P. 22 – 27.
    • Jungsuwadee P. Doxorubicin-induced cardiomyopathy: an update beyond oxidative stress and myocardial cell death / P. Jungsuwadee // Cardiovasc. Regen. Med. – 2016. – Vol. 3. 1127 p.
    • Lymanets T. The free radical oxidation role in the development of anthracycline-induced cardiotoxicity in patients with acute leukemia in the presence of concomitant ischemic heart disease / T. Lymanets, I. Skrypnyk, G.Maslova // Hematologica. – 2015. – Vol. 100, Suppl.1. – P.641.
    • Mungrue I.N. The role of NOS in heart failure: lessons from murine genetic models / I.N. Mungrue, M. Husain, D.J. Stewart // Heart Fail. Rev. – 2002. – Vol. 7. – P. 407 – 422.
    • Pacher P. Potent metalloporphyrin peroxynitrite decomposition catalyst protects against the development of doxorubicin-induced cardiac dysfunction / P.Pacher, L. Liaudet, P.Bai [et al.] // Circulation. – 2003. – Vol. 107. – P. 896 – 904.
    • Raj S. Anthracycline-induced cardiotoxicity: a review of pathophysiology, diagnosis and treatment / S. Raj, V.I. Franco, S.E. Lipshultz // Curr. Treat. Options Cardiovasc. Med. – 2014. – Vol. 16. – P. 315 – 323.
    • Weinstein D. M. Cardiac peroxynitrite formation and left ventricular dysfunction following doxorubicin treatment in mice / D.M. Weinstein, M.J. Mihm, J.A. Bauer // J. Pharmacol. Exp. Ther. – 2000. – Vol. 294. – P. 396–401.
    • Zhu S.-G. Dietary nitrate supplementation protects against doxorubicin-induced cardiomyopathy by improving mitochondrial function / S.-G. Zhu, R.C.Kukreja, A. Das [et al.] // J. Am. Coll. Cardiol. – 2011. – Vol. 57. – P. 2181 – 2189.
    Publication of the article «World of Medicine and Biology» №3(57), 2016 year, 035-040 pages, index UDK [616.155.392+616.12-005.4]:615.099-07-084