| About the author: |
Kostitska I. O. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The research was carried out on 22 mature male Wistar rats. They were divided into 3 groups: 1 – the control group (6 animals), 2 – 8 animals with streptozotocin-induced diabetes mellitus (DM) (modeled with a single intraperitoneal injection at a dose of 6 mg per 100 g), 3 – 8 treated animals with streptozotocin-induced diabetes mellitus (DM) (since the 14-th day of DM development were treated with the injection of exenatide (Byetta) of 0.04 mcg / 100g body weight once a day subcutaneously). Diabetic gastroparesis is observed in rats on the 56-th day of streptozotocin-induced diabetes and is morphologically manifested in: destructive changes in the neurons of intermuscular plexus (vacuolar dystrophy, apoptosis); axonal degeneration of unmyelinated nerve fibers; apoptosis and necrosis of the interstitial cells of Cajal; vacuolar dystrophy of myocytes and the development of diabetic microangiopathy. The usage of exenatide in the early stages of DM development (till the 28-th day) leads to normalization of glycemic profile and restoration of the structural organization of the components of intermuscular nerve plexus and smooth myocytes of stomach muscle membrane and demonstrates the adequacy of the proposed treatment. However, the usage of exenatide as monotherapy during 1,5 months leads to: the increase of glucose level and HbА1с, destructive changes of neurons and interstitial cells of Cajal of intermuscular nerve plexus and smooth myocytes of stomach muscle membrane. Taking into consideration the conducted research, it can be asserted that the usage of exenatide as monotherapy in diabetic gastro paresis is appropriate only in the early stages of the disease, and in the late ones – only in combination with other antidiabetic drugs. |
| Tags |
stomach, interstitial cells of Cajal, diabetic gastro paresis, exenatide, streptozotocin-induced diabetes mellitus |
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| Publication of the article |
«World of Medicine and Biology» №3(57), 2016 year, 113-118 pages, index UDK 616.379-008.64+ 616.3-02 |
