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    Gasyuk А.P., Vynnyk N.І., Gasyuk D.YU.


    About the author: Gasyuk А.P., Vynnyk N.І., Gasyuk D.YU.
    Type of article Review article
    Annotation Cell division is one of the most important biological phenomena, causing the reproductive process. It is this phenomenon that provides the continuous existence of generations of cells and the whole organisms. The most common form of division is mitosis. It encompasses such major processes as the dna reduplication, synthesis of the protein component of chromosomes and achromatin apparatus, doubling of the cytocentrums and formation of the energy storage, required for the mitotic division. Mitotic apparatus is a temporary structure of the cell, which ensures the movement of chromosomes during the cell division (mitosis). Current publications on the complex organization of the kinetochore and centrosome, which is a “cellular process” that manages the dynamics of the morphology of cell, as well as the regulator of the mitotic cycle, have been analyzed. Kinetochores are distinguished as the locus in quo of the mitotic assemblage control point of the cleavage spindle and are represented as the protein structures that ensure the attachment of microtubules of centrosomes and mitotic apparatus during the mitosis.
    Tags mitosis, mitotic apparatus, centrosome, kinetochore
    • Braun T. A. Genomyi: [Per. S Angl.] / T. A. Braun // – M.; Izhevsk: Institut Kompyuternyih Issledovaniy, - 2011. – 921 s.
    • Lyuina B. Kletki / Pod. Red. B. Lyuina, L. Kassimerisa, V. P. Lingappyi [i dr.] // – M.: Binom. Laboratoriya Znaniy, - 2011. – 952 s.
    • Omelyanchuk L. V. Osnovnyie Sobyitiya Kletochnogo Tsikla: Ih Regulyatsiya I Organizatsiya / L. V. Omelyanchuk, S. A. Fedorova // – Novosibirsk: Ngu, - 2010. – 47 S.
    • Alieva I. B. The Vertebrate Primary Cilium Is A Sensory Part Of Centrosomal Complex In Tissue Cells In Is “Sleeping Beauty” In Cultured Cells / I. B. Alieva, I. A. Vorobjev // Cell Biol. Int. – 2004. – Vol. 28. – P.139–150.
    • Assembly And Mechanosensory Function Of Focal Adhesions: Experiments And Models / A. D. Bershadsky, C. Ballestrem, L. Carramusa [et al.] // Eur. J. Cell Biol. – 2006. – Vol. 85 (3/4). – P. 165–173.
    • Cell Cycle Progression And De Novo Centriole Assembly After Centrosomal Removal In Untransformed Human Cells / Y. Uetake, J. Loncarek, J. J. Nordberg [et al.] // Eur. J. Cell Biol. – 2007. – Vol. 176. – P. 173–182.
    • Chikhirzhina E. Chromatin Structure: The Role Of “Linker” Proteins / E. Chikhirzhina, G. Chikhirzhina, A. Polyanichko // Biomedical Spectroscopy And Imaging. – 2014. – Vol. 3. – P. 345–358.
    • Duensing S. Centrosome Abnormalities, Genomic Instability And Carcinogenic Progression / S. Duensing, K. Munger // Biochim. Biophys. Acta. – 2001. – Vol. 1471. – P. 81–88.
    • Goepfert T. M. The Centrosome –Associated Aurora/Ipl-Like Kinase Family / T. M. Goepfert, B. R. Brinkley // Curr. Top. Develop. Biol. – 2000. – Vol. 49. –  P. 331–342.
    • Luger K. New Insights Into Nucleosome And Chromatin Structure: An Ordered State Or A Disordered Affair? / K. Luger, M. L. Dechassa, D. J. Tremethick // Nat. Rev. Mol. Cell Biol. – 2012. – Vol. 13. – P. 436–447.
    • Molecular Biology Of The Cell / B. Alberts, J. Alexander, L. Julian [et al.]. – New York: Garland Science, - 2014 1464 p.
    • Pihan G. A. Centrosome Abnormalities And Chromosome Instability Occur Together In Pre-Invasive Carcinomas / G. A. Pihan, J. Wallace, Y. Zhou [et al.] // Cancer Res. – 2003. – Vol. 63. – P. 1398–1404.
    • Terra S. La The De Novo Centriole Assembly Pathway In Hela Cells: Cell Cycle Progression And Centriole Assembly/Maturation / S. La Terra, C. N. English, P. Hergert [Et Al.] // J. Cell. Biol. – 2005. – Vol. 168. – P. 713–722.
    • Uzbekov R. Clockwise or anticlockwise? Turning the centriole triplets in the right direction! / R. Uzbekov, C. Prigent // febs lett. – 2007. – Vol. 581. – P. 1251–1254.
    • Wilkinson C. J. A Proteomic Approach In The Inventory Of The Human Centrosome / C. J. Wilkinson, J. S. Andersen, M. Mann [et al.] // Centrosomes In Development And Disease / E. A. Nigg (Ed.). – Willey-Vch Verlag Gmbh & Co., Kgaa, Weinheim, - 2003. – P. 125–139.
    Publication of the article «World of Medicine and Biology» №1(59), 2017 year, 191-194 pages, index UDK 611.018/15