Grintsova N. B., Pernakov N. S.

COMPLEX HEAVY METAL SALTS EFFECT ON MORPHOLOGICAL FUNCTIONING CONDITION OF THE NUCLEI OF GANGLION NEURONS OF WHITE MALE RATS’ CEREBELLAR CORTEX

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About the author:	Grintsova N. B., Pernakov N. S.
Heading	EXPERIMENTAL MEDICINE
Type of article	Scentific article
Annotation	In order to analyze the dynamics of morphological and morphometric nuclear rearrangements of cortical cerebellar Purkinje cells under prolonged exposure (for 90 days) on the body of copper sulfate, zinc and iron experiment was conducted on 48 white adult male rats weighing 200-250g, aged 5 -8 months. We used an electron microscope method. It was found that the combined effect of copper sulfate, zinc and iron on the body has nuclear device ganglion neurons in the cerebellar cortex sufficiently expressive toxicity. The degree of morphological mutations in the nuclear unit is in direct proportion to the duration of the experiment. In the nuclei of ganglion neurons develop nonspecific changes of polymorphic nature, which is reversible in the early stages of experience and irreversible, mainly necrobiotic character (chromatolysis, pycnosis and reksis) in most of the neurons within a timeline.
Tags	cerebellum, heavy metal salts, ganglion neurons, chromatin, karyolysis, karyopycnosis, karyoreksis, necrosis
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Publication of the article	«World of Medicine and Biology» №2(60), 2017 year, 132-135 pages, index UDK 611.817.1.084/.085:613.632:616.831.71-092.9