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    Fedotenkova N. N.

    DOSE-DEPENDENT POLYPEPTIDE COMPLEX “VERMILAT” INFLUENCE ON SALIVARY GLAND TISSUES HEMOCOAGULATIVE AND PROOXYDATIVE FEATURES IN THE INTACT ANIMALS


    About the author: Fedotenkova N. N.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation Peptide preparation “Vermilat” was extracted by Eisenia foetida, segmented worm, acid extraction at two-covalent ions presence. This preparation represents lyophilized sterile apyrogenic powder. It belongs to cytomedins, low-molecular regulatory peptides, has molecular weight equal to 2-8 kDa. It is characterized by such basic aminoacids as arginine and lysine high content and was developed as connective tissue metabolism corrector. The present work aim was assessing the submandibular salivary gland tissue influence on following indices: the hemostatic ones such as recalcification time, thrombin time, euglobuline clot lysis time as well as lipids peroxidative oxidation index such as malonic dialdehyde and the antioxidative system one such as superoxidedismutase. All parameters were assessed before the experiment start, in 2 weeks and in 1 month. The results received testified that “Vermilat” lowered submandibular salivary gland tissues thromboplastic and fibrinolytic features. The preparation did not change peroxidative lipid oxidation processes and weakened insignificantly its hemocoagulative qualities in a therapeutic dose.
    Tags regulatory peptides, “Vermilat”, hemostasis, prooxidative-antioxidative status
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    Publication of the article «World of Medicine and Biology» №2(60), 2017 year, 164-168 pages, index UDK [616.316+616.151.5]-092.9:615.36