EnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Kornatsky V.M., Dorokhina A.M.

    MOLECULAR-GENETIC MECHANISMS OF INDIVIDUAL STRESS-RESISTANCE


    About the author: Kornatsky V.M., Dorokhina A.M.
    Heading LITERATURE REVIEWS
    Type of article Review article
    Annotation he review provides information on current views on individual stress resistance. It is shown that the determining factors of vulnerability or resistance to stress are: psychosocial causes, in particular social support and religion, neurobiological features of the individual, are genetically determined, and epigenetic influences. Adrenergic, hypothalamic-pituitary-adrenal, serotonergic and dopaminergic systems provide adaptation of the organism to unfavorable conditions of existence. Genetic factors that are largely responsible for interindividual variability of stress resistance include: genetic predisposition (polymorphism of candidate genes of mental disorders and modulator genes), as well as intergenic interactions. Epigenetic processes are considered intermediate mechanisms, through which the negative effect of stress factors on the human genome is realized. Stress, especially in the early stages of the development of the body, modulates the activity of stress-limiting systems of the body, which can lead to mental disorders. A special role is assigned to microRNAs, considering them potential biological non-invasive markers and at the same time therapeutic targets. Understanding the molecular genetic traits that underlie stress resistance will be an important step in improving the diagnosis, prevention and treatment of stress disorders.
    Tags stress, genes, еpigenetics, stress resilience, microRNA, single nucleotide polymorphism
    Bibliography
    • Lehtsier V.L. Meditsina 4P v optike filosofskoy i mediko-antropologicheskoy narrativistiki / V.L. Lehtsier // Izvestiya Samarskogo nauchnogo tsentra Rossiyskoy akademii nauk. – 2015. – T.17, No.5 (3). – C. 994 – 1000.
    • Meerson F. Adaptatsiya, stress i profilaktika / Meerson F. – M.: Nauka, 1981. – 279 s.
    • Rozanov V.A. Stress-indutsirovannyie epigeneticheskie fenomenyi – esche odin veroyatnyiy biologicheskiy faktor suitsida / V.A. Rozanov // Suitsidologiya. – 2015. – T. 6, No. 3 (20). – S. 3-19.
    • Al-Hadethe A. Prevalence of traumatic events and PTSD symptoms among secondary school students in Baghdad / A. Al-Hadethe, N. Hunt, Sh. Thomas [et al.] // European Journal of Psychotraumatology. – 2014. – Vol. 5. – P. 23928.
    • Balakathiresan N.S. Serum and amygdala microRNA signatures of posttraumatic stress: fear correlation and biomarker potential / N.S. Balakathiresan, R. Chandran, M. Bhomia [et al.] // J Psychiatr Res. – 2014. – Vol. 57. – P. 65-73.
    • Binder E.B. Association of FKBP5 Polymorphisms and Childhood Abuse With Risk of Posttraumatic Stress Disorder Symptoms in Adults / E.B. Binder, R.G. Bradley, W. Liu [et al.] // JAMA. – 2008. – Vol. 299 (11). – P. 1291–1305.
    • Blanc J. Religious Beliefs, PTSD, Depression and Resilience in Survivors of the 2010 / Earthquake / J. Blanc, G.J. Rahill, S. Laconi [et al.] // J Affect Disord. – 2016. – Vol. 190. – P. 697–703.
    • Bradley R.G. Influence of Child Abuse on Adult Depression Moderation by the Corticotropin-Releasing Hormone Receptor Gene / R.G. Bradley, E.B. Binder, M.P. Epstein [et al.] // Arch Gen Psychiatry. – 2008. – Vol. 65 (2). – P. 190–200.
    • Brummett B.H. Associations of a regulatory polymorphism of monoamine oxidase-A gene promoter (MAOA-uVNTR) with symptoms of depression and sleep quality / B.H. Brummett, A.D. Krystal, I.C. Siegler [et al.] // Psychosom Med. – 2007. – Vol. 69 (5). – P. 396-401.
    • Chen R.J. MicroRNAs as biomarkers of resilience or vulnerability to stress / R.J. Chen, G. Kelly, A. Sengupta [et al.] // Neuroscience. – 2015. – Vol. 305. – P. 36-48.
    • Drury S.S. The Association of a Novel Haplotype in the Dopamine Transporter with Preschool Age Posttraumatic Stress Disorder / S.S. Drury, Z.H. Brett, C.J. Henry [et al.] // Child Adolesc. Psychopharmacol. – 2013. – Vol. 23. – P. 236–243.
    • Ebner K. Individual differences in stress susceptibility and stress inhibitory mechanisms / K. Ebner, N. Singewald // Current Opinion in Behavioral Sciences. – 2017. – Vol. 14. – P. 54–64.
    • Feder A. Psychobiology and molecular genetics of resilience / A. Feder, E.J. Nestler, D.S. Charney // Nat Rev Neurosci. – 2009. – Vol. 10 (6). – P. 446–457.
    • Friedman R.C. Most mammalian mRNAs are conserved targets of microRNAs / R.C. Friedman, K.K. Farh, C.B. Burge // Genome Res. – 2009. – Vol. 19 (1). – P. 92–105.
    • Funke B. COMT genetic variation confers risk for psychotic and affective disorders: a case control study / B. Funke, A.K. Malhotra, C.T. Finn [et al.] // Behav. Brain Funct. – 2005. – Vol. 1. – P. 19.
    • Gillespie C.F. Risk and resilience: genetic and environmental influences on development of the stress response / C.F. Gillespie, J. Phifer, B. Bradley [et al.] // Depress Anxiety. – 2009. – Vol. 26 (11). – P. 984-992.
    • Goldstein D.S. Evolution of concepts of stress / D.S. Goldstein, I.J. Kopin // Stress. – 2007. – Vol. 10 (2). – P. 109-120.
    • Gudsnuk K. Epigenetic Influence of Stress and the Social Environment / K. Gudsnuk, A. Frances // Champagne ILAR J. – 2012. – Vol. 53 (3-4). – P. 279–288.
    • Hettema J.M. COMT Contributes to Genetic Susceptibility Shared Among Anxiety Spectrum Phenotypes / J.M. Hettema, S. An, J. Bukszar // Biol. Psychiatry. – 2008. – Vol. 64. – P. 302–310.
    • Ising M. Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls / M. Ising, A.M. Depping, A. Siebertz // Eur J Neurosci. – 2008. – Vol. 28 (2). – P. 389-398.
    • Kendler K.S. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs / K.S. Kendler, N.R. Wray // Nature Genetics. – 2013. – Vol. 45. – P. 984–994.
    • Kolassa I.T. The Risk of Posttraumatic Stress Disorder After Trauma Depends on Traumatic Load and the Catechol-OMethyltransferase Val158Met Polymorphism / I.T. Kolassa, S. Kolassa, V. Ertl // Biol. Psychiatry. – 2010. – Vol. 67. – P. 304–308.
    • Kremen W.S. Twin Studies of Posttraumatic Stress Disorder: Differentiating Vulnerability Factors from Sequelae // W.S. Kremen, K.C. Koenen, N. Afari [et al.] // Neuropharmacology. – 2012. – Vol. 62 (2). – P. 647–653.
    • Kuepper Y. MAOA-uVNTR genotype predicts interindividual differences in experimental aggressiveness as a function of the degree of provocation / Y. Kuepper, P. Grant, C. Wielpuetz [et al.] // Behav Brain Res. – 2013. – Vol. 247. – P. 73-78.
    • Lamoshi A.Y. Religion as a Resilience Tool to Manage Stress in Adolescents: Islamic Approach / A.Y. Lamoshi // Global Journal of HUMAN-SOCIAL SCIENCE: H Interdisciplinary. – 2015. – Vol. 15 (3). Available at: http://socialscienceresearch.org/index.php/GJHSS/article/viewFile/1480/1421.
    • Michopoulos V. Association of CRP genetic variation and CRP level with elevated PTSD symptoms and physiological responses in a civilian population with high levels of trauma / V. Michopoulos, A.O. Rothbaum, T. Jovanovic [et al.] // Am. J. Psychiatry. – 2015. – Vol. 172 (4). – P. 353–362.
    • Nemoda Z. Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood / Z. Nemoda, A. Szekely, M. Sasvari-Szekely // Neurosci Biobehav Rev. – 2011. – Vol. 35 (8). – P. 1665–1686.
    • Nestler E.J. Transgenerational Epigenetic Contributions to Stress Responses: Fact or Fiction? / E.J. Nestler // PLoS Biol. – 2016. – Vol.14(3). – P. e1002426.
    • Nguyen T.B. Serotonin transporter polymorphism (5HTTLPR), severe childhood abuse and depressive symptom trajectories in adulthood / T.B. Nguyen, J.M. Gunn, M. Potiriadis [et al.] // British Journal of Psychiatry. – 2015. – Vol. 1 (1). – P. 104-109.
    • Osório C. Adapting to Stress: Understanding the Neurobiology of Resilience / C. Osório, T. Probert, E. Jones [et al.] // Behav Med. – 2016. – P. 1-16.
    • Ozbay F. Social support and resilience to stress: from neurobiology to clinical practice / F. Ozbay , D.C. Johnson , E. Dimoulas [et al.] // Psychiatry (Edgmont). – 2007. – Vol. 4 (5). – P. 35–40.
    • Renthal W. Chromatin regulation in drug addiction and depression / W. Renthal, E.J. Nestler // Dialogues Clin Neurosci. – 2009. – Vol. 11. – P. 257–268.
    • Rodrigues S.M. Oxytocin receptor genetic variation relates to empathy and stress reactivity in humans / S.M. Rodrigues, L.R. Saslow, N. Garcia [et al.] // Proc Natl Acad Sci U S A. – 2009. – Vol. 106 (50). – P. 21437-21441.
    • Ryan J. Biological underpinnings of trauma and post-traumatic stress disorder: focusing on genetics and epigenetics / J. Ryan, I. Chaudieu, M.L. Ancelin [et al.] // Epigenomics. – 2016. – Vol. 8 (11). – P. 1553-1569.
    • Sun H.S. Epigenetics of the Depressed Brain: Role of Histone Acetylation and Methylation / H.S. Sun, P.J. Kennedy, E.J. Nestler // Neuropsychopharmacology. – 2013. – Vol. 38 (1). – P. 124–137.
    • Voltas N. Association study of monoamine oxidase-A gene promoter polymorphism ( MAOA-uVNTR ) with self-reported anxiety and other psychopathological symptoms in a community sample of early adolescents / N. Voltas, E. Aparicio, V. Arija // J. Anxiety Disord. – 2015. – Vol. 31. – P. 65–72.
    • Wood S.K. Resilience to the effects of social stress: Evidence from clinical and preclinical studies on the role of coping strategies / S.K. Wood, S. Bhatnagar // Neurobiology of Stress. – 2015. – Vol. 1. – P. 164–173.
    • Yehuda R. Lower methylation of glucocorticoid receptor gene promoter 1F in peripheral blood of veterans with post-traumatic stress disorder / R. Yehuda, J.D. Flory, L.M. Bierer [et al.] // Biol. Psychiatry. – 2015. – Vol. 77(4). – P. 356–364.
    • Zhou J. Dysregulation in microRNA Expression Is Associated with Alterations in Immune Functions in Combat Veterans with Post-Traumatic Stress Disorder / J. Zhou, P. Nagarkatti, Y. Zhong [et al.] // PLOS ONE. – 2014. – Vol. 9 (4). – P. e94075.
    • Zhou Z. Genetic variation in human NPY expression affects stress response and emotion / Z. Zhou, G. Zhu, A.R. Hariri [et al.] // Nature. – 2008. – Vol. 452 (7190). – P. 997–1001.
    Publication of the article «World of Medicine and Biology» №2(60), 2017 year, 183-190 pages, index UDK 612.176+577.21