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    Demkovych, Yu. Bondarenko, P. Hasiuk

    HUMORAL IMMUNE REACTIVITY DISORDERS IN EXPERIMENTAL PARODONTITIS AND THEIR CORRECTION BY FLAVONOL


    About the author: Demkovych, Yu. Bondarenko, P. Hasiuk
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation In the article investigated disorders of humoral immune defense (immunoglobulins A, M, G classes and circulating immune complexes (CIC)) on the 7th, 14th and 30th days of experimental bacterial-immune periodontitis, and the possibility of correcting them with the corvitin (quercetin). Its use for 7 days intramuscularly at a dose of 100 mg / kg positively affected to the course of the inflammatory process with this modeled pathology. At the same time, the content of the CIC in the blood serum was determined as an important link in the pathogenesis of immune damage during experimental inflammation in periodontal tissues. The dynamics of the CIC indices was similar to the dynamics of immunoglobulins on the 14th day of the experiment, that is, their concentration was significantly higher, as compared with the indices of intact animals. The use of corvitin caused decrease concentration of circulating immune complexes in the blood serum as compared to animals that did not treat. Thus, it has been proved that flavonoid corvitin, influencing to immune processes, promote to restrict the inflammatory reaction in the periodontal complex in this pathology.
    Tags Periodontitis, immunoglobulins, circulating immune complexes, immune status, corvitin
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    Publication of the article «World of Medicine and Biology» №3(61), 2017 year, 097-100 pages, index UDK 614. 312 – 76 – 18:4
    DOI 10.26724/2079-8334-2017-3-61-97-100