• Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    Moyseyenko N. N.


    About the author: Moyseyenko N. N.
    Type of article Scentific article
    Annotation The neurohumoral properties’s changes in the hypothalamus as a result of TON are unknown. The purpose of the study: to study neurohumoral dysfunction in the traumatic optical neuropathy’s pathogenesis. Methods. The traumatic damage to the orbital part of the right optic nerve was reproduced in 60 sexually mature rabbits in the experiment. There were two groups of animals of 30 individuals: intact and experimental. Electronic microscopy of the hemithin and ultrathin sections and the morphometry of the cranial part of the right optic nerve and the suprachismic nucleus of the hypothalamus one month after the injury. It has been established that traumatic damage to the orbital part of the optic nerve causes reactive edema and destructive changes in the cranial part of the optic nerve and the suprachiasmic nucleus of the hypothalamus. The reducing the volumetric neurosecretory granules density and the pycnomorphic cells’ number at the last stage of development increasing were detected. This reduces the corticosteroids production that cause inflammatory reactive damage to the optic nerve. Conclusion. Hence, neurohumoral dysfunction is an important mechanism for the pathogenesis of traumatic optical neuropathy, and its correction will have positive effects for treatment.
    Tags traumatic optical neuropathy, neurohumoral dysfunction, suprachiasmic nucleus of the hypothalamus, neurosecretory granules
    • Bove L. A pilot study on the relation between cisplatin neuropathy and vitamin E / L. Bove, M. Picardo, V. Maresca [et al.] // - J Exp Clin Cancer Res. - 2001 Jun, Vol. 20(2), P. 277-280.
    • Bulyk R.Ye. Ul"trastruktura nejroniv supraxiazmatychnyx yader hipotalamusa za umov svitlovoyi depryvaciyi.Visnyk naukovyx doslidzhen / R.Ye. Bulyk // - 2008, Vol.1(50), P. 78-80.
    • Doghri T. Post-traumatic anterior pituitary insufficiency / T. Doghri, R. Bouguerra, G. Ezzaouia [et al.] // - Apropos of 2 cases. Ann Endocrinol (Paris). – 1996, Vol. 57(2), P. 117-121.
    • Einaudi S. The effects of head trauma on hypothalamic-pituitary function in children and adolescents / S. Einaudi, C. Bondone // - Curr Opin Pediatr. – 2007, Vol. 19(4), P. 465-470.
    • Faden A. I. Progressive inflammatory-mediated neurodegeneration after traumatic brain or spinal cord injury / A. I. Faden, J. Wu, B. A. Stoica [et al.] // - Br J Pharmacol. - 2016 Feb, Vol. 173(4), P. 681-691.
    • Hall E. D. Peroxynitrite-mediated protein nitration and lipid peroxidation in a mouse model of traumatic brain injury / E. D. Hall, M. R. Detloff, K. Johnson // - J Neurotrauma. - 2004 Jan, Vol. 21(1), P. 9-20.
    • Helwig B.G. Aging alters regulation of visceral sympathetic nerve responses to acute hypothermia / B. G. Helwig, S. Parimi, C. K. Ganta // - Am J Physiol Regul Integr Comp Physiol. - 2006 Sep, Vol. 291(3), P.573-579.
    • Klingbeil G. E. Anterior hypopituitarism: a consequence of head injury / G. E. Klingbeil, P. Cline // - Arch Phys Med Rehabil. - 1985 Jan, Vol. 66(1), P. 44-46.
    • Kaulfers A. M. Endocrine dysfunction following traumatic brain injury in children / A.M. Kaulfers, P. F. Backeljauw, K. Reifschneider // - J Pediatr. - 2010 Dec, Vol. 157(6), P.894-899.
    • Levytskyi V. A. Histoultrastructure of facial nerve in normal and under experimental neuropathy / V. A. Levytskyi, N. I. Shovkova // - Vis-nyk morfologii. – 2009, Vol.1, P. 38-43.
    • Morganti-Kossmann M. C. TGF-beta is elevated in the CSF of patients with severe traumatic brain injuries and parallels blood-brain barrier function / M. C. Morganti-Kossmann, V. H. Hans, P. M. Lenzlinger // J Neurotrauma. - 1999 Jul, Vol. 16(7), P. 617-628.
    • Morganti-Kossmann M. C. Role of cerebral inflammation after traumatic brain injury: a revisited concept / M.C. Morganti-Kossmann, M. Rancan, V.I. Otto // - Shock. - 2001 Sep, Vol. 16(3), P.165-177.
    • Morganti-Kossmann M.C. Modulation of immune response by head injury / M. C. Morganti-Kossmann, L. Satgunaseelan, N. Bye // - Injury. - 2007 Dec, Vol. 38(12), P. 1392-1400.
    • Mesquita J. Trauma and the endocrine system / J. Mesquita, A. Varela, J. L. Medina // - Endocrinol Nutr. - 2010 Dec, Vol. 57(10), P. 492-499.
    • Moiseenko N. M. Morphofunctional aspects of restorative processes in the optic nerve after traumatic injury under the influence of high doses of corticosteroids / N. M. Moiseenko // -J.ophthalmol.(Ukraine) – 2015, Vol. 6, P. 37-41.
    • Pasichnichenko O. M. Fiziolohiyi vehetatyvnoyi nervovoyi systemy / O. M. Pasichnenko // posib. dlya samostiynoyi roboty. К. – 2006, 62 p.
    • Su D. H. Post-traumatic anterior and posterior pituitary dysfunction / D. H. Su, Y.C. Chang, C.C. Chang // - J Formos Med Assoc. - 2005 Jul, Vol. 104(7), P. 463-467.
    • Sarikcioglu L. Walking track analysis: an assessment method for functional recovery after sciatic nerve injury in the rat / L. Sarikcioglu, B.M. Demirel, A. Utuk // Folia Morphol (Warsz). - 2009 Feb, Vol. 68(1), P. 1-7.
    • Schmidt A. P. Guanosine prevents thermal hyperalgesia in a rat model of peripheral mononeuropathy / A. P. Schmidt, L. Paniz, C. Schallenberger // - J Pain. – 2010, Feb, Vol. 11(2), P.131-141.
    • Zhurakivska O.Уа. The age features of morphological changes of the pituitary neurohypophysis system in the later stages of streptozotocin diabetes / O.Уа. Zhurakivska // - Journal World of Medicine and Biology. – 2014 Vol. 4, P. 123-127.
    Publication of the article «World of Medicine and Biology» №3(61), 2017 year, 138-142 pages, index UDK 617.731-007.2+617.731-088.85+617.7-001.22+617.7-001.15+617.7-009+617.7-073.178+6016-092.2
    DOI 10.26724/2079-8334-2017-3-61-138-142