Bezshapochny S. B. Sonnik N. B., Ivanchenko S. A., Grishina I. S.

APPLICATION OF EFFECTIVE COMBINATIONS IN TREATMENT OF RINOSINUSITIS

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About the author:	Bezshapochny S. B. Sonnik N. B., Ivanchenko S. A., Grishina I. S.
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	The article describes the problem of treatment of patients with acute and chronic bacterial rhinosinusitis. To date, the benefits of combined medication are due to its ease of use and economic utility. For such drugs, a combination of decongestants hydrochloride with an antiseptic miramistin. An analysis of the results of treatment of patients with the use of this combination in adult concentrations was 0.1% / 0.01%, for children - 0.05% / 0.01%. Starting from 2 days in patients of the main group, the average value of severity of symptoms was less compared to the control. Patients in the main group noted better tolerability of the drug compared to the control group, the latter often had complaints of dryness of the mucous membrane. The number of hospital stay days decreased by 1.3 days in the main group compared to the control group. The obtained results testify to the effectiveness of the combination of hydrochloride with miramistin in the complex treatment of acute and chronic bacterial rhinosinusitis.
Tags	bacterial rhinosinusitis, xylometazoline hydrochloride, miramistin
Bibliography	Instruktsiya k meditsinskomu primeneniyu lekarstvennogo sredstva «Rinomistin». Nakaz Ministerstva okhorony zdorovia Ukrainy № 85 vid 11.02.2016 r. Unifikovanyi klinichnyi protokol pervynnoi, vtorynnoi (spetsializovanoi) ta tretynnoi (vysokospetsializovanoi) medychnoi dopomohy «Hostryi rynosynusyt». Elektronnyi dokument «Adaptovana klinichna nastanova, zasnovana na dokazakh «Hostryi rynosynusyt», - 2016. Lopatyn A.S. Nazalnыe dekonhestantы: starыe y nove formы/ A.S. Lopatyn// Otorynolarynholohyia. – 2011. – No.6 (65). – S.17-23. Puhlik S. M. Nazalnyie dekongestantyi – za i protiv / S. M. Puhlik // RinologIya. -2008. – No.4. – S. 36-51. Popovych V. I. Hostryi pisliavirusnyi rynosynuit: suchasni pohliady na etiopatohenez, diahnostyku ta likuvannia / V. I. Popovych // Zdorovia Ukrainy. Tematychnyi nomer «Pulmonolohiia, Alerholohiia, Rynolarynholohiia». – 2015. – No. 2 (30) – S.18-19. Chow A. W. IDSA clinical practice guidelines for acutebacterial rhinosinusitis in children and adults / A.W. Chow, M.S. Benninger [et al.] // Clin Infect Dis. – 2012. – Vol. 54:1. 41 p. Fokkens W. J. Position Paper on Rhinosinusitus and Nasal Polyps (EPOS) / W. J. Fokkens //  Rhinology supplement Vol. 23: 1. – 2012. –298 р.
Publication of the article	«World of Medicine and Biology» №4(62), 2017 year, 009-011 pages, index UDK 616. 211 – 002.2 – 056
DOI	10.26724/2079-8334-2017-4-62-9-11