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    Savrun T. Y. Kocherha Z. R. Chekotun T. V. Bykovskaia O. A. Kyslova Yu. O.

    STUDY OF ACUTE KIDNEY INJURY IN PREMATURE NEWBORNS AFFECTED BY PERINATAL HYPOXIA


    About the author: Savrun T. Y. Kocherha Z. R. Chekotun T. V. Bykovskaia O. A. Kyslova Yu. O.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation The article presents research findings on the characteristics of acute kidney injury in premature newborns affected by perinatal hypoxia, depending on the gestational age. Clinical manifestations of hypoxic kidney injury were estimated by the severity of edema syndrome, urinary syndrome and hourly diuresis. The study revealed significantly higher levels of cystatin C in blood serum, as well as lipocalin and interleukin-18 (р<0.01) levels in urine over 2-4 days after birth in premature newborns with hypoxic kidney injury as compared to premature infants without any signs of perinatal hypoxia. The study of renal blood flow showed significant decrease in the indices of peak systolic velocity in the renal artery trunk and pulsation index (р<0.05). It has been established that the differences of renal injury markers were more evident in premature newborns of the gestational age less than 32 weeks. The obtained findings indicate that the indices of serumal cystatin C, lipocalin and interleukin-18 in urine, in combination with renal blood flow evaluation are effective in early diagnosis of acute kidney injury in newborns affected by perinatal hypoxia.
    Tags premature newborns, acute kidney injury, cystatin C, interleukin-18, lipocalin, renal blood flow
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    Publication of the article «World of Medicine and Biology» №4(62), 2017 year, 071-076 pages, index UDK 616-037-084:616.152.21:616.61:616-053.32
    DOI 10.26724/2079-8334-2017-4-62-71-76