EnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    O. I. Gevka

    CHANGES IN PERINEURIAL AND HEMATOENDONEURIAL BARRIERS OF THE SCIATIC NERVE IN PACLITAXEL-INDUCED PERIPHERAL NEUROPATHY


    About the author: O. I. Gevka
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation The absence of a unified concept of paclitaxel-induced peripheral neuropathy morphogenesis determines the need for a detailed morphological study. This paper demonstrates ultramicroscopic changes in the structure of the perineurial and the hematoendoneurial barriers of the sciatic nerve in albino rats caused by paclitaxel. Chemotherapeutic agent was administered intraperitoneally at a dose of 2 mg/kg of body weight, each alternate day, 4 times. The experiment period was 120 days; during the experiment, samples were collected for morphometric study and electron microscopic study. In the experiment, there were determined changes in endoneurial blood flow manifested themselves as congestion, morphological signs of transendothelial transport abnormalities, dystrophic changes in endothelial cells of varying severity and stages, thickening and dissociation of the basement membrane. In the perineurium, the disorganization of fiber and cellular elements, deformation of the processes, hydropic dystrophy of perineurial cells and impaired permeability of the perineurium progressing within the first months of the experiment and gradually disappearing until the end of the experiment were observed.
    Tags Paclitaxel, perineurial barrier, hematoendoneurial barrier, peripheral neuropathy
    Bibliography
    • Hevka O. I. Patomorfohenez eksperymentalnoi paklitaksel-indukovanoi peryferiinoi neiropatii / O. I. Hevka // Svit medytsyny ta biolohii. – 2014. – No.2 (44). – S. 105-110.
    • Brewer J. R Chemotherapy-induced peripheral neuropathy: current status and progress / J. R. Brewer, G. Morrison, M. E. Dolan // Gynecol. Oncol. - 2016. № 140, P. - 176–183.
    • Fukuda Y. A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy / Y. Fukuda, Y. Li., R. A. Segal // Front Neurosci. -  2017. - № 11: 481. Published online 2017 Aug 31.
    • Gornstein E. L. Neurotoxic mechanisms of paclitaxel are local to the distal axon and independent of transport defects / E. L. Gornstein, T. L. Schwarz // Exp Neurol. – 2017. - № 288. - P.153-166.
    • Horner S. A. Lack of the vascular targeting agent ZD6126 following repeated i.v. dosing in the rat / S. A. Horner, S. Gould, J. P. Noakes // Cancer Their. – 2004. – Vol. 3 (7). – P. 783 – 791.
    • Han Y. Pathobiology of cancer chemotherapy-induced peripheral neuropathy (CIPN) / Y. Han, M. T. Smith // Front Pharmacol. – 2013. - №4: 156. – P. 6- 21.
    • Kirchmair R. Therapeutic Angiogenesis Inhibits or Rescues Chemotherapy-induced Peripheral Neuropathy: Taxol- and Thalidomide-induced Injury of Vasa Nervorum is Ameliorated by VEGF / R. Kirchmair, A. B. Tietz, E. Panagiotou [et al.] // Mol. Ther. – 2007. – Vol. 15. – P. 69–75.
    • 8.Kumar S. Clinical trials and progress with paclitaxel in ovarian cancer / S. Kumar, H. Mahdi, C. Bryant [et al.] // Int J Womens Health. – 2010. - №2. - P. 411–427.
    • 9.Pushkarev V. M. Effects of low and high concentrations of antitumour drug taxol in anaplastic thyoid cancer cells / V. M. Pushkarev, D. V. Starenki, V. A. Saenko [et al.] // Exp. Oncol. – 2009. – № 31 (1). – P. 16 – 21.
    • Shemesh O. A. Paclitaxel induces axonal microtubule spolar reconfigurationand impaired organelle transport: implications for the pathogenesis of paclitaxel-induced neuropathy / O. A. Shemesh, M. E. Spira // Acta Neuropathol. - 2010. – №119(2) - P. 235-248.
    • Starobova H. Pathophysiology of Chemotherapy-Induced Peripheral Neuropathy / H. Starobova, I. Vetter // Front Mol Neurosci. - 2017. - № 10, 174 р.
    • Tofthagen C. Peripheral Neuropathy Caused by Paclitaxel and Docetaxel: An Evaluation and Comparison of Symptoms / C.Tofthagen, R. D. McAllister, C. Visovsky // J Adv Pract Oncol. – 2013. - № 4(4). - P. 204–215.
    • Tony K. Y. Lim. Peripheral Nerve Injury Induces Persistent Vascular Dysfunction and Endoneurial Hypoxia, Contributing to the Genesis of Neuropathic Pain /Tony K.Y. Lim, Xiang Q. Shi, Julia M. Johnson // Journal of Neuroscience.- 2015, № 35 (8).-P. 3346-335.
    • Velasco R. Taxane-Induced Peripheral Neurotoxicity Toxics / R.Velasco, J. Bruna // – 2015. - №3. - P. 152-169.
    Publication of the article «World of Medicine and Biology» №4(62), 2017 year, 116-122 pages, index UDK 611.835+ 616.833-009+615.277
    DOI 10.26724/2079-8334-2017-4-62-116-122