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    Hladkykh F.V., Stepaniuk N.H., Vernygorodskii S.V.

    MORPHOLOGICAL CHANGES OF INTERNAL OR-GANS IN TREATMENT OF ADJUVANT ARTHRITIS


    About the author: Hladkykh F.V., Stepaniuk N.H., Vernygorodskii S.V.
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation Nonsteroidal anti-inflammatory drugs are widely used in many fields of medicine for the treatment of inflammatory processes of various etiologies and is one of the most clinically meaningful groups of drugs. Serious side effects of these drugs are their gastrotoxicity, nephrotoxicity, hepatotoxicity, and others. In previous studies, we have proved the effectiveness of combined use of Ukrainian antispasmodics with the polytropical pharmacological properties of vinoborone and a non-steroidal anti-inflammatory drug ibuprofen for potentiating the therapeutic properties of the latter and diminishing its toxicity to the mucous membrane of the stomach. The aim of the study was to characterize the effect of ibuprofen and its combination with vinoboron on the liver, kidney and adrenal glands, according to morphological studies on the model of adjuvant arthritis in rats. The study was conducted on 28 sexually mature nonlinear male rats. Adjuvant arthritis was modeled by sublingual administration of full Freund's adjuvant. Treatment of adjuvant arthritis was performed from day 14 to day 28, by intragastric administration of the investigational drugs. The conducted study showed that vinoboron against ibuprofen in the treatment of experimental adjuvant arthritis reduces hepatotoxic and nephrotoxic effects of ibuprofen.
    Tags vinoboron, ibuprofen, adjuvant arthritis, non-steroidal anti-inflammatory drugs, hepatotoxicity, nephrotoxicity
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    Publication of the article «World of Medicine and Biology» №4(62), 2017 year, 127-131 pages, index UDK [615.262:616.276]:616.72-002.772:612.08
    DOI 10.26724/2079-8334-2017-4-62-127-131