EnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    A. M. Goltsev, O. O. Lykhytskyi

    THE ROLE OF IMMUNE-INFLAMMATORY PROCESSES AND OXIDATIVE STRESS IN THE MECHANISMS OF REPARATIVE OSTEOGENESIS IN RATS WITH AN OPEN FRACTURE OF THE MANDIBLE ON THE BACKGROUND OF OSTEOPOROSIS


    About the author: A. M. Goltsev, O. O. Lykhytskyi
    Heading EXPERIMENTAL MEDICINE
    Type of article Scentific article
    Annotation In the experimental study, the parameters of immune-inflammatory processes and oxidative stress in different terms of reparative osteogenesis in rats with an open fracture of the mandible on the background of osteoporosis were studied. It was proved that under these conditions the course of reparative osteogenesis was characterized by a number of metabolic changes: at 14 days after injury, the highest activity of immune-inflammatory reactions and oxidative stress was characteristic, and at 30 days - the maximum intensity of processes of angiogenesis and osteogenesis. Most of the biochemical parameters of blood serum of rats normalized at 45 days after fracture of the mandible.
    Tags immune-inflammatory reactions, oxidative stress, reparative osteogenesis, fracture of the mandible
    Bibliography
    • Batura I. A. Osteonnyie konstruktsii bedrennoy kosti kryis pri dlitelnom vvedenii gidrokortizona / I. A. Batura // Visnyk Bilotserkivs'koho derzhavnoho ahrarnoho universytetu – 2005, Vol. 33, P.300-304.
    • Deev R. V. Effektivnost gen-aktivirovannogo osteoplasticheskogo materiala s plazmidnyimi DNK, soderzhaschimi gen VEGF, v zameschenii kostnyih defektov / R. V. Deev, I. Ya. Bozo, A. Yu. Drobyishev [et al.] // Probl. kriobiologii i kriomeditsinyi, - 2013, Vol. 23(3), P. 355-358.
    • Fukui T. p22phox mRNA expression and NADPH oxidase activity are increased in aortas from hypertensive rats / T. Fukui, N. Ishizaka, Rajagopalan [et al.] // - Circ. Res., - 1997, Vol. 80(1), P. 45-51.
    • Janssens K. Transforming growth factor-beta1 to the bone / K. Janssens, P. ten Dijke, S. Janssens [et al.] // - Endocr. Rev., - 2005, Vol. 26(6), P. 743-774.
    • Kochetov G. A. Prakticheskoe rukovodstvo po enzimologii / G. A. Kochetov // - M.: Vyissh. – 1980 shk.
    • Kostyuk V. A. Prostoy i chuvstvitelnyiy metod opredeleniya aktivnosti superoksiddismutazyi, osnovannyiy na reaktsii okisleniya kvertsitina / V. A. Kostyuk, A. I. Potapovich, Zh. V. Kovaleva // - Vopr. med. Himii, 2, - 1990, Р.88-91.
    • Korzh N. A. Reparativnaya regeneratsiya kosti: sovremennyiy vzglyad na problemu. Sistemnyie faktoryi, vliyayuschie na zazhivlenie pereloma / N. A. Korzh, N. V. Deduh, O. A. Nikolchenko // - (Soobschenie 3). Ortopediya, travmatologiya i protezirovanie, - 2006, Vol. 2, P. 93-99.
    • Menshikov V. V. Laboratornyie metodyi issledovaniya v klinike: Spravochnik / V. V. Menshikov // - M.: Meditsina – 1987.
    • Rolik, O. V., & Zasadnyuk, I. A. Nezroshchennya dovhykh kistok (analiz, faktory ryzyku, likuval'na taktyka) / O. V. Rolik, I. A. Zasadnyuk // Ortopedyya, travmatolohyya y protezyrovanye, - 2005, Vol. 2, P. 61-64.
    • Saito M. Poor bone quality in diabetes and arterioscelerosis / M. Saito // - Clin Calcium, - 2009, Vol. 19(9), P.1257-1268.
    • Sikora V. Z. Nekollagenovyie belki kostnogo matriksa kak markeryi remodelirovaniya kosti / V. Z. Sikora, M. V. Pogorelov, Tkach // - Ukrayinskiy morfologichniy almanah, - 2011Vol. 9(3-D),P. 28-35.
    • Vladimirov Yu. V. Perekisnoe okislenie lipidov v biologicheskih membranah / Yu. V. Vladimirov, A. I. Archakov // - M.: Nauka – 1972.
    • Zaichko N. V. Okyslyuval'na modyfikatsiya bilkiv syrovatky krovi yak marker aktyvnosti revmatoyidnoho artrytu ta yiyi zminy pid vplyvom farmakoterapiyi amizonom, indometatsynom, nimesulidom / N. V. Zaichko // Visnyk Vinnyts'koho derzhavnoho medychnoho universytetu, - 2003, Vol. 7(2/2), P.664 - 666.
    • Zubov D. A. Tsitokinovaya immunoregulyatsiya reparativnoy regeneratsii kostnoy tkani kultivirovannyimi mezenhimalnyimi stvolovyimi kletkami / Zubov D. A., Oksimets, V. M. // - Travma,- 2008, Vol. 9(2), P.145-153. 
    Publication of the article «World of Medicine and Biology» №4(62), 2017 year, 132-136 pages, index UDK 616-003(616.314-089.23:616.71-007.234):599.323.4
    DOI 10.26724/2079-8334-2017-4-62-132-136