N.V. Malko, P.A. Hasiuk, V.V. Ivanchyshyn, N.V. Hasiuk

CHANGES IN BIOCHEMICAL PARAMETERS OF BLOOD SERUM AND GINGIVAL HOMOGENATES WITH EXPERIMENTAL GINGIVITIS

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About the author:	N.V. Malko, P.A. Hasiuk, V.V. Ivanchyshyn, N.V. Hasiuk
Heading	EXPERIMENTAL MEDICINE
Type of article	Scentific article
Annotation	Inflammatory periodontal diseases is an urgent problem not only in dentistry, but also in general medicine, due to their high prevalence and negative effects on a human body causing significant economic consequences. As a result, the bioregulation of biochemical processes is often damaged, due to it, at a certain level of damage, different diseases, including dental ones, occur and develop. Moreover, the study of the impact of the combined action of xenobiotics on biochemical tissue indicators of a growing up human body, the development of new means of correction, which are based on inhibition of proteases, hydrolases, kinin system, normalization of tissue penetration, enhancing the action of protective factors of a human body, ensuring the sustainability of periodontal tissues to the negative influence of environmental agents, are important and poorly understood issues. Research purpose – to study the biochemical parameters of blood serum and homogenates of the gums in experimental animals with gingivitis caused by the combined action of heavy metals and deficiency of fluorine and iodine. Consequently, experimental studies have convincingly demonstrated that in experimental gingivitis under the influence of the adverse environmental factors the levels of inflammatory markers ‒ elastase and urease, as well as the indices of the protease-inhibitory system increased.
Tags	Inflammatory periodontal diseases, xenobiotics, experimental animals, protease-inhibitory system
Bibliography	Bezvushko E.: Features of formation of periodontal pathology in children living in different environmental conditions. Visnyk stomatologii. - 2006; (2): P. 97-101. Kryuchenko N.: The presence of fluoride in underground waters of Ukraine and the diseases associated with it. Search Env Geochem. - 2001; (1): P. 9-13. Leus P.: Pilot project: „Optimization system of dental care to children population” / P. Leus // - Bull Dent. - 2010; (2): P. 141-146. Lozovyi M. The results of monitoring study the effects of air quality on the health of the child population / M. Lozovyi, A. Nikitina, L. Kuzmenko // - Sci Bull NMU A. A. Bogomolets. - 2010; (27): P. 143-145. Levytsky A. Experimental methods of playback of gingivitis / A. Levytsky, O. Denga, O. Makarenko [et al.] // - Odessa. - 2013: 14 р. Ostapko O.: The influence of environmental factors on the level of dental health for Ukrainian children. Naukovyi visnyk Nacional’nogo medychnogo universytety imeni O.O. Bogomol’tsya. - 2007; (1): P. 162-164. Petrovska M.: The health of the population in Lviv region as a result of reaction to changes in the environment. Bull Lviv Univ Ser Geogr. - 2011; (39): P.267-277. World Health Organization.: Oral Health Surveys Methods. - 2013; 5th ed. Who Yeneva. Yakovlev M. Endotoxin aggression” as premorbidity or a universal factor of pathogenesis of diseases of humans and animals / M. Yakovlev // - Successes Modern Biochem. - 2003; №(1): P.31-40. Vynogradov V. Pharmacology with the recipe / V. Vynogradov, E. Katkova, E. Mukhin // - 2009; 5th ed. Spetslit, SPb.
Publication of the article	«World of Medicine and Biology» №4(62), 2017 year, 149-152 pages, index UDK 611. 26.34 – 12.01
DOI	10.26724/2079-8334-2017-4-62-149-152