| About the author: |
Yaremenko L. M., Grabovоy O. M., Shepelev S. E. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
In order to analyze the dynamics of β-tubulin expression in the sensorimotor cortex during the modeling of transient ischemia against the background of previous sensitization by brain antigen and immunocorrection of their consequences, an experiment was performed on 185 white mature male rats weighing 260-290 g. Histological, immunohistochemical, densitometric and statistical methods of research. It was found that sensitization with brain antigen leads to diffuse degenerative changes in the cerebral cortex, accompanied by a decrease in β-tubulin expression. Previous sensitization by brain antigen leads to an increase in the severity of brain damage and a decrease in the expression of β-tubulin in acute circulatory disturbance. The use of immunophane provides a reduction in changes in β-tubulin expression in the sensorimotor cortex caused by both sensitization of the brain antigen and in combination with transient impairment of cerebral blood flow. |
| Tags |
brain, sensitization by brain antigen, brain ischemia, β-tubulin, imunophane |
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| Publication of the article |
«World of Medicine and Biology» №4(62), 2017 year, 173-178 pages, index UDK 616.831-005.4.001.57:612.017.1:611.813.1 |
| DOI |
10.26724/2079-8334-2017-4-62-173-178 |
