| About the author: |
O.Yu. Toziuk, O.V. Kryvoviaz, T.I. Ivko, A.S. Voronkina |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
According to experimental studies, sodium 2-(tetrazolo[1,5-c]quinazoline-5-ylthio)acetate (KB-28 compound) shows an expressive actoprotective action under normal conditions. The work investigated the influence of KB-28 compound in the conditions of chronic immobilization stress. The study revealed that the administration of this substance maintains a high level of performance in rats. This confirms the presence in KV-28 of actoprotective effect. It has been also proven that the action of the test substance is maintained in the complicated conditions of the experiment. In addition, it is established that a stress-protective effect is inherent to sodium 2-(tetrazolo[1,5-c]quinazoline-5-ylthio)acetate which was manifested by rapid adaptation of animals to chronic immobilization stress. The effectiveness of KB-28 compound was significantly superior to the reference substance on the 12th and 18th day of the study. |
| Tags |
sodium 2-(tetrazolo[1,5-c]quinazoline-5-ylthio)acetate, 2-ethylthiobenzimidazole hydrobromide, chronic immobilization stress |
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| Publication of the article |
«World of Medicine and Biology» №1(63), 2018 year, 160-163 pages, index UDK 547.856.1:616.45-001.1/.3 |
| DOI |
10.26.724/2079-8334-2018-1-63-160-163 |
