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    Tsekhmistrenko O.S., Tsekhmistrenko S.I., Bityutskyy V.S. Melnichenko O.M., Oleshko O.A.

    BIOMIMETIC AND ANTIOXIDANT ACTIVITY OF NANOCRYSTALLINE CERIUM DIOXIDE


    About the author: Tsekhmistrenko O.S., Tsekhmistrenko S.I., Bityutskyy V.S. Melnichenko O.M., Oleshko O.A.
    Heading LITERATURE REVIEWS
    Type of article Review article
    Annotation The conducted analysis of scientific literature shows the widespread application in biology and medicine of nano compounds of cerium dioxide that exhibit biomimetic and antioxidant activity. High biocompatibility degree, low toxicity and catalytic activity of nanodispersed cerium dioxide allows us to consider it as a promising nanobio material for biomedical applications. The role of nanocrystalline cerium dioxide in protecting cells from oxidative stress is characterized. Oxygen non-stoichiometry, associated with it ability to participate in oxidative-reduction processes in a living cell, as well as the ability to auto regeneration ensure high efficiency of nanodispersed cerium dioxide using. Cerium (Ce) is a rare-earth element that belongs to lanthanides. The uniqueness of Cerium is due to the fact that it can exist in different oxidation states (Ce3+ and Ce4+), unlike most other rare earth metals, which are predominantly in trivalent state. Cerium itself has no biological significance in the physiology of mammals, but Ce3+ soluble salts are traditionally used for biomedical purposes because of their bacteriostatic, bactericidal, immunomodulatory, and antitumor activity. The biological activity of cerium dioxide nanoparticles is determined by its oxygen non-stoichiometry, which depends on the size of the nanoparticle and the surface ligand. High degree of biocompatibility, low toxicity and catalytic activity of nanodispersed cerium dioxide allow it to be considered as a promising nanomaterial for biomedical applications. However, today all the possible mechanisms of its biological activity are poorly understood. It has been shown that nanoseria can act as a mimetic of superoxide dismutase, catalase, some oxidase, oxidoreductase and phosphatase, and it is also able to participate in the neutralization of active forms of nitrogen. Nanocerium acts as a mimetic of superoxide dismutase (SOD) and catalase, and its efficiency in the neutralization of radicals is proportional to the concentration of Ce3+ ions on the surface of the particle. SOD-like activity of NDC is comparable to that of natural enzyme. In the case of superoxide anion dismutration, the formation of hydrogen peroxide and transitional compound - cerium Ce(ООН)(OH)3 hydroperoxide on the surface of nanodispersed cerium dioxide. NDC is able to inactivate a highly active hydroxyl radical. The presence of cerium dioxide nanoparticles reduces the concentration of OH∙. Numerous studies have shown that SeO2 nanoparticles effectively protect cells against the effects of hydrogen peroxide and other peroxides. The catalase activity can be changed by modifying cerium dioxide nanoparticles with various metal ions. The compounds of nanodispersed cerium dioxide exhibit oxidase properties. In this case, the pH-dependent peroxidase-like activity is established. It has been established that the size and surface ligands affect the reactivity of nano dispersed cerium dioxide. The possibility of repeated use of SeO2 nanoparticles as an antioxidant was revealed. NDC is able to inactivate active forms of nitrogen and nitrogen-containing free radicals. The ability of cerium dioxide nanoparticles to inactivate peroxynitrile (ONOO-) is shown, which causes damage to a number of biomolecules by adsorption of the surface of carbonate ions. New data on the catalytic activity of nanodispersed cerium dioxide prove its similarity to phosphatase. CeO2 is able to catalyze the hydrolysis of organic phosphate ester. The ability of cerium dioxide nanoparticles to decompose fighting poisonous substances has been revealed. Thus, it is possible to adjust its antioxidant and prooxidant properties and enzyme activityby changing the stoichiometry of the nanodispersed cerium dioxide. There is a need for further research on the functions, properties and role of NDC in order to improve the integration of biomimetic nanomaterials into the human body and animals, which is the basis for new scientific developments in the field of biology, chemistry, medicine for the prevention, diagnosis and treatment of various diseases.
    Tags nano-particles, cerium dioxide, mimetics, oxidative stress, superoxide dismutase
    Bibliography
    • Kozik VV, Shcherbakov AB, Ivanova OS, Spivak NIa, Ivanov VK. Sintez i biomeditcinskie primeneniia nanodispersnogo dioksida tceriia. Tomsk: Izdatelskii Dom Tomskogo gos. universiteta; 2016. 476 s.
    • Tcekhmistrenko OS, Tcekhmistrenko SI. Ontogeneticheskie osobennosti funktcionirovaniia antioksidantnoi sistemy perepelov. Aktualnye problemy intensivnogo razvitiia zhivotnovodstva. Gorki. 2016; 19(2):335-9.
    • Chekman IS, Horchakova NO, Simonov PV. Biolohichno aktyvni rechovyny yak nanostruktury: biokhimichnyi aspekt. Klinichna farmatsiia. 2017; 21(2):15-22.
    • Shadura YuM, Bitiutskyi VS, Spivak MIa, Melnychenko OM, Shcherbakov OB, Demchenko OA, ta in. Doklinichni doslidzhennia hostroi toksychnosti nanokrystalichnoho dioksydu tseriiu. Visnyk ZhNAEU. Ser.: Veterynariia. 2015; 2(50):358-63.
    • Batinić-Haberle I. Rebouças JS, Spasojević I. Superoxide Dismutase Mimics: Chemistry, Pharmacology, and Therapeutic Potential. Antioxid Redox Signal. 2010; 13(6):877-918.
    • Bityutskyy VS, Tsekhmistrenko ОS, Tsekhmistrenko SI, Spyvack MY, ShaduraUM. Perspectives of cerium nanoparticles use in agriculture. The Animal Biology. 2017; 19(3):9-17.
    • Casals E, Gusta MF, Piella J, Casals G, Jiménez W, Puntes V. Intrinsic and Extrinsic Properties Affecting Innate Immune Responses to Nanoparticles: The Case of Cerium Oxide. Frontiers in Immunology. 2017; 8(970).
    • Celardo I. De Nicola M, Mandoli C, Pedersen J Z, Traversa E, Ghibelli L. Pharmacological potential of cerium oxide nanoparticles. Nanoscale. 2011; 3:1411-20.
    • Charbgoo F, Ramezani M, Darroudi M. Bio-sensing applications of cerium oxide nanoparticles: Advantages and disadvantages. Biosensors and Bioelectronics.2017; (15):33-43.
    • Dalapati R, Sakthivel B, Ghosalya MK, Dhakshinamoorthy A, Biswas S. A cerium-based metal-organic framework having inherent oxidase-like activity applicable for colorimetric sensing of biothiols and aerobic oxidation of thiols. CrystEngComm. 2017; 19(39):5915-25.
    • Das S, Dowding JM, Klump KE, McGinnis JF, Self W, Seal S. Cerium oxide nanoparticles: applications and prospects in nanomedicine. Nanomedicine (Lond). – 2013; 8(9):1483-508.
    • Dowding J.M, Seal S, Self WT. Cerium oxide nanoparticles accelerate the decay of peroxynitrite (ONOO−). Drug Delivery and Translational Research. 2013; 3(4):375-9.
    • Dowding J.M, Dosani T, Kumar A, Seal S, Self WT. Cerium oxide nanoparticles scavenge nitric oxide radical (˙NO). Chem. Commun. 2012; (48):4896-8.
    • Ferraro D, Tredici IG, Ghigna P, Castillio-Michel H, Falqui A, Di Benedetto C, et al. Dependence of the Ce(III)/Ce(IV) ratio on intracellular localization in ceria nanoparticles internalized by human cells. Nanoscale. 2017; 9(4):1527-38.
    • Gil D, Rodriguez J, Ward B, Vertegel A, Ivanov V, Reukov V. Antioxidant Activity of SOD and Catalase Conjugated with Nanocrystalline Ceria. Bioengineering. 2017; 4(1):18.
    • Grulke E, Reed K, Beck M, Huang X, Cormack A, Seal S. Nanoceria: factors affecting its pro- and antioxidant properties. Environmental Science: Nano. 2014; 1(5):429-44.
    • Jian He, Zhou L, Liu J, Yang L, Zou L, Xiang J, et al. Modulation of surface structure and catalytic properties of cerium oxide nanoparticles by thermal and microwave synthesis techniques. Applied Surface Science. 2017; 402:469-77.
    • Jiao X, Song H, Zhao H, Bai W, Zhang L, Lv Y. Well-redispersed ceria nanoparticles: Promising peroxidase mimetics for H2O2 and glucose detection. Anal. Methods. 2012; 4:3261-7.
    • Kwon H.J, Cha MY, Kim D, Kim DK, Soh M, Shin K, et al. Mitochondria-targeting ceria nanoparticles as antioxidants for Alzheimer’s disease. ACS Nano. 2016; 10:2860-70.
    • Lee SS, Song W, Cho M, Puppala HL, Nguyen P, Zhu H, et al. Antioxidant Properties of Cerium Oxide Nanocrystals as a Function of Nanocrystal Diameter and Surface Coating. ACS Nano. 2013; 7(11):9693–703.
    • Lushchak V.I. Free radicals, reactive oxygen species, oxidative stresses and their classifications. The Ukrainian Biochemical Journal. 2015; 87(6):11-8.
    • McCormack RN, Mendez P, Barkam S, Neal CJ, Das S, Seal S. Inhibition of nanoceria’s catalytic activity due to Ce3+ site-specific interaction with phosphate ions. The Journal of Physical Chemistry C. 2014; 118(33):18992-9006.
    • Naganuma T. Shape design of cerium oxide nanoparticles for enhancement of enzyme mimetic activity in therapeutic applications. Nano Research. 2017; 10(1):199-217.
    • Nelson BC, Johnson ME, Walker ML, Riley KR, Sims CM. Antioxidant cerium oxide nanoparticles in biology and medicine. Antioxidants. 2016; (5):15.
    • Pezzini I, Marino A, Del Turco S, Nesti C, Doccini S, Cappello V, et al. Cerium oxide nanoparticles: the regenerative redox machine in bioenergetic imbalance. Nanomedicine (Lond). 2017; 12(4):403-16.
    • Pirmohamed T, Dowding JM, Singh S, Wasserman B, Heckert E, Karakoti AS, et al. Nanoceria exhibit redox state-dependent catalase mimetic activity. Chemical Communications (Cambridge, England). 2010; 46(16):2736-8.
    • Pruchniak M.P, Araźna M, Demkow U. Biochemistry of Oxidative Stress. Adv Exp Med Biol. 2016; 878):9-19.
    • Roll N, Tsehmistrenko S. Processes of peroxidation of lipids and proteins in organs of rabbits considering the age-old aspect. Вісник Львівського університету. Сер. Біологічна. 2016; 73:191-6.
    • Singh S. Cerium oxide based nanozymes: Redox phenomenon at biointerfaces Biointerphases. 2016; 11(4):04B202(12).
    • Sun L, Ding Y, Jiang Y, Liu Q. Montmorillonite-loaded ceria nanocomposites with superior peroxidase-like activity for rapid colorimetric detection of H2O2. Sensors and Actuators B: Chemical. 2017; 239:848-56.
    • Tsai YY, Oca-Cossio J, Agering K, Simpson NE, Atkinson MA, Wasserfall CH, et al. Novel synthesis of cerium oxide nanoparticles for free radical scavenging. Nanomedicine (Lond). 2007; 2(3):325-32.
    • Walkey C, Das S, Seal S, Erlichman J, Heckman K, Ghibelli L, et al. Catalytic Properties and Biomedical Applications of Cerium Oxide Nanoparticles. Environmental science Nano. 2015; 2(1):33-53.
    • Wang G, Zhang J, He X, Zhang Z, Zhao Y. Ceria Nanoparticles as Enzyme Mimetics. Chinese Journal of Chemistry. 2017; 35(6):791-800(10).
    • Wei H, Wang E. Nanomaterials with enzyme-like characteristics (nanozymes): next-generation artificial enzymes. Chem Soc Rev. 2013; 42(14):6060–93.
    • Xue Y, Luan Q, Yang D, Yao X, Zhou K. Direct Evidence for Hydroxyl Radical Scavenging Activity of Cerium Oxide Nanoparticles. J. Phys. Chem. 2011; 115(11):4433-8.
    • Zhang J, Naka T, Ohara S, Kaneko K, Trevethan T, Shluger A, et al. Surface ligand assisted valence change in ceria nanocrystals. Phys. Rev. B. 2011; 84:045411.
    • Zhang Z, Zhang X, Liu B, Liu J. Molecular Imprinting on Inorganic Nanozymes for Hundred-fold Enzyme Specificity. Journal of the American Chemical Society. 2017; 139(15):5412-9.
    • Zhu A, Sun K, Petty H. Titanium doping reduces superoxide dismutase activity, but not oxidase activity, of catalytic CeO2 nanoparticles. Inorg Chem. Commun. 2012; 15:235-7.
    Publication of the article «World of Medicine and Biology» №1(63), 2018 year, 196-201 pages, index UDK 577.1:620.3:546.655.3/4
    DOI 10.267254/2079-8334-2018-1-63-196-201