| About the author: |
V.Z. Netyazhenko, N.V. Netyazhenko, T.Y. Malchevska, O.M. Plienova |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
A comparative evaluation of the state of thrombocyte-plasma haemostasis was performed in patients of both sexes with acute and chronic forms of ischemic heart disease. It was found that women of all compared groups showed high platelet and procoagulant activity in comparison with men, despite the use of antiaggregant therapy and anticoagulants. MI in women is more unfavorable with increasing frequency of atrial fibrillation paroxysms and Lown III-IV extrasystolic arrhythmia (by 11.4% and 10.0%), cardiogenic shock by 6.8%, early postinfarction angina and pulmonary edema by 5 % compared to men. The delay in interventional intervention is associated with a 2.7-fold increase in mortality in women compared to men. A postmenopausal period of up to 5 years should be considered as an independent predictor of cardiovascular events. The postmenopausal period lasting less than 5 years in women with stable ischemic heart disease is accompanied by prothrombotic and procoagulant shifts of platelet-plasma hemostasis, even with antiplatelet treatment and is associated with an increase in the risk of adverse course of probable MI 7.1-fold (OR 7.1, 95% CI, 6-9.2, p = 0.046). |
| Tags |
thrombotic complications, atherosclerosis, women, ischemia |
| Bibliography |
- Aradi D, Komócsi A, Price MJ. For the Tailored Antiplatelet Treatment Study Collaboration. Efficacy and safety of intensified antiplatelet therapy on the basis of platelet reactivity testing in patients after percutaneous coronary intervention: systematic review and meta- analysis. Int J Cardiol ; 2013;167:2140–8.
- Breet NJ, van Werkum JW, Bouman HJ. Comparison of platelet function tests in predicting clinical outcome in patients undergoing coronary stent implantation. JAMA ; 2010; 303:754–62.
- Chirumamilla AP, Maehara A, Mintz GS., High platelet reactivity on clopidogrel therapy correlates with increased coronary atherosclerosis and calcification: a volumetric intravascular ultrasound study. J Am Coll Cardiol Img ; 2012; 5:540–9.
- Harrison P, Mackie I, Mumford A, Briggs C, Liesner R, Winter M, Machin S. Guidelines for the Laboratory Investigation of Heritable Disorders of Platelet Function British Committee for Standards in Haematology. British Society for Haematology; 2011; 4: 47-84.
- Levine GN, Bates ER, Blankenship JC. ACCF/AHA/ SCAI guideline for percutaneous coronary intervention: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and Interventions. J Am Coll Cardiol; 2011; 58:e44–122.
- Price MJ, Berger PB, Teirstein PS. for the GRAVITAS Investigators. Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trial. JAMA ; 2011; 305:1097–105.
- Steg PG, James SK, Atar D, Badano LP, Lundqvist CB, Borger MA, Fox KA. ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. European heart journal; 2012; 33(20):2569-2619.
- Stone GW, Witzenbichler B, Weisz G. for the ADAPT-DES Investigators. Platelet reactivity and clinical outcomes after coronary artery implantation of drug-eluting stents (ADAPT-DES): a prospective multicentre registry study. Lancet; 2013; 382:614–23.
- Tantry US, Bonello L, Aradi D, Price MJ, Jeong YH, Angiolillo DJ, Gurbel PA. Consensus and update on the definition of on-treatment platelet reactivity to adenosine diphosphate associated with ischemia and bleeding. Journal of the American College of Cardiology; 2013; 62(24), 2261-2273.
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| Publication of the article |
«World of Medicine and Biology» №2(64), 2018 year, 065-070 pages, index UDK 616.1-055.2:616.151.5 |
| DOI |
10.26724/2079-8334-2018-2-64-65-70 |
