O.S. Khukhlina, A.A Antoniv, I.V. Dudka, T.V. Dudka, O.E. Mandryk

THE STATE OF BLOOD LIPID SPECTRUM AND THE INDICATORS OF INSULIN RESISTANCE IN PATIENTS WITH NONALCHOLIC STEATOHEPATITIS WITH OBESITY AND HYPERTENSIVE DISEASE

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About the author:	O.S. Khukhlina, A.A Antoniv, I.V. Dudka, T.V. Dudka, O.E. Mandryk
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	The study was aimed to find out the possible interaction of the blood lipid spectrum, the level of glycemia and the degree of insulin resistance on the clinical course of non-alcoholic steatohepatitis (NASH) on the background of obesity, depending on the presence of comorbid hypertensive disease (HD) II stage. The total of 90 patients with NASH were examined: of which 30 patients with NASH and obesity I degree (1 group), 30 patients with NASH and a comorbid flow of HD II stage and obesity I degree (group 2), 30 patients with HD II stage and obesity I degree (group 3). The studies of lipid spectrum in blood in patients with NASH showed results of the lipid spectrum of the blood and the insulin resistance degree in patients with non-alcoholic steatohepatitis and comorbidity with obesity and hypertension disease second degree. In patients with non-alcoholic steatohepatitis and obesity without accompanying hypertension, the following changes in the blood lipid profile are characteristic: the maximum increase in the content of triacylglycerol in the blood, the likely increase in the content of total cholesterol and low proatherogenic lipoproteins, the probable decrease in anti-atherogenic high-density lipoproteins, which, with the addition of the comorbid HDII stage it is likely to deepen, in addition to the indicator of hypertriacylglycerolemia. The reason for the progression of the metabolic syndrome against non-alcoholic steatohepatitis and hypertension is lipid distress syndrome with an increase in total blood cholesterol, low proatherogenic lipoprotein, and a deficiency of high-density anti-atherogenic lipoprotein.
Tags	nonalcoholic steatohepatitis, obesity, hypertonic disease, blood lipid spectrum, insulin resistance
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Publication of the article	«World of Medicine and Biology» №2(64), 2018 year, 085-088 pages, index UDK 616.153:616.36-003.826:616-056.527
DOI	10.26724/2079-8334-2018-2-64-85-88