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    Volosovets T.N., Dyadyk O.A., Feleshtynska O.Ya.

    MANIFESTATION OF CHRONIC RECURRENT APHTOUS STOMATITIS IN CROWN DISEASE


    About the author: Volosovets T.N., Dyadyk O.A., Feleshtynska O.Ya.
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation The frequency of manifestations of chronic recurrent aphthous stomatitis in the exacerbation of Crohn's disease was analyzed. The results of studying the clinical manifestations of Crohn's disease from the oral cavity in 86 patients showed that in 33 (38.4%) patients there were changes in the oral cavity, in particular, chronic recurrent aphthous stomatitis in 9 (10.46%), which is confirmed by the results histological examination of the oral mucosa, namely the presence of granulomatous inflammation. The results of intestinal studies by capsular endoscopy and colonoscopy with biopsy also confirm the presence of granulomatous changes from the mucosa of the large intestine, which corresponds to the diagnosis of Crohn's disease. In 19 (22.1%) patients, manifestations from the oral cavity for 8 + 1.2 days precede intestinal symptoms. In 14 (16.3%) patients, clinical manifestations from the oral cavity were manifested with intestinal disorders. The diagnosis of chronic recurrent aphthous stomatitis in Crohn's disease was confirmed by the results of a histological examination of the pathologically altered mucous membrane of the oral cavity, with characteristic granulomatous changes that correlate with changes in the intestinal mucosa. Detected characteristic granulomatous changes from the oral cavity without the presence of intestinal manifestations, require both local and general pathogenetic treatment in the early stages of the disease.
    Tags chronic recurrent aphthous stomatitis, Crohn's disease, biopsy, granulomatous inflammation
    Bibliography
    • Danylevskyi MF, Borysenko AV, Antonenko MYu ta in. Zakhvoryuvannya slyzovoï obolonky porozhnyny rota. K.: Medytsyna, 2010; 640 s. [in Ukrainian]
    • Boyko TI. Vnekishechnyie proyavleniya vospalitelnykh zabolevaniy kishechnika. Novosti meditsiny i farmatsii. Dnepropetrovsk. 2010; 18(341). [in Russian]
    • Markovskyi VD, Tumanskyi VO, Sorokina IV ta in. Patomorfolohiya: nats. pidruch. za red. Markovskoho VD, Tumanskoho VO. Kyiv: VSV «Medytsyna». 2015; s.40-52, 621-655. [in Ukrainian]
    • Savychuk OV, Zaytseva YeM, Nemyrovych YuP, Beketova HP. Likuvannya khronichnoho retsydyvuyuchoho aftoznoho stomatytu. Sovremennaya stomatologiya. 2015; 2: 37 – 39. [in Ukrainian]
    • Tokmanova YeV, BulkinaNV, Meleshina OV, Lomakina DO. Sovremennyye aspekty patogeneza i kompleksnoy terapii khronicheskogo retsidiviruyushchego aftoznogo stomatita. Fundamental research. 2012; (4). [in Russian]
    • Harikishan G, Reddy NR, Prasad H, Anitha S. Oral Crohn’s disease without intestinal manifestations. J Pharm Bioallied Sci. 2012; 4: 431–434.
    • Karman B Lankarani, Gholam Reza Sivandzadeh, Shima Hassanpour. Oral manifestation in inflammatory bowel disease: a review. Inflamm Bowel Dis. 2013; 19(46): 8571 – 8579.
    • Lourenço SV, Hussein TP, Bologna SB, Sipahi AM, Nico MM. Oral manifestations of inflammatory bowel disease: a review based on the observation of six cases. J Eur Acad Dermatol Venereol. 2010; 24: 204–207.
    • Vavricka SR, Schoepfer A, Scharl M, Lakatos PL, Navarini A, Rogler G. Extraintestinal Manifestations of Inflammatory Bowel Disease. Inflamm Bowel Dis. 2015; 21:1982–1992.
    • Rosai J, Ackerman. Surgical Pathology. Seventh ed. Edited by J.Rosai. Elsevier Inc. 2011; 1 (2,3) 25-95.
    Publication of the article «World of Medicine and Biology» №3(65), 2018 year, 042-045 pages, index UDK 616.3 –002.157.2–036.12–039.35–02:616.344–002–031.84
    DOI 10.26724/2079-8334-2018-3-65-42-45