РусскийEnglishУкраїнська
  • Main
  • Useful links
  • Information for Contributors
  • About
  • Editorial board

  • Article
    O. M. Didushko, P. R. Herych, I. V. Cherniavska, R.I. Yatsyshyn, V.I. Pankiv

    INFLUENCE OF THE COMPLEX TREATMENT OF HYPOTHYROIDISM ON THE LEPTIN LEVEL IN PATIENTS WITH PRIMARY HYPOTHYROIDISM


    About the author: O. M. Didushko, P. R. Herych, I. V. Cherniavska, R.I. Yatsyshyn, V.I. Pankiv
    Heading CLINICAL MEDICINE
    Type of article Scentific article
    Annotation The total of 188 patients with primary hypothyroidism and 30 people without an impaired function of thyroid gland were examined and compared according to sex and age. While evaluating leptin level in blood serum of patients with hypothyroidism, we noticed that an increase of the body mass in these patients is accompanied by the growth of its concentration. We revealed a more expressed hyperleptinemia in patients with postsurgical hypothyroidism. Basic treatment with levothyroxine and especially its comorbidity with atorvastatin contributed to the improvement of the clinical state of the patients, to the decrease of hypothyroidism manifestations, to the decrease of body mass. Addition of atorvastatin to the complex treatment had a significant impact on the leptin level in patients with hypothyroidism and obesity independently from hypothyroidism etiology.
    Tags Hypothyroidism, hyperleptinemia, obesity, treatment
    Bibliography
    • Altshuler NE, Petunina NA, Nikolaev AP., Chernyshova TV. Sravnitelnyy analiz kontsentratsii gormonov zhirovoy tkani, pokazateley lipidnogo obmena i insulinorezistentnosti pri subklinicheskom gipotireoze v zavisimosti ot nalichiya / otsutstviya zamestitelnoy terapii levotiroksinom Clinical and experimental thyroidology. 2011;7(3):53–8. [in Russian]
    • Didushko OM. Vzaiemozviazok mizh pokaznykamy insulinorezystentnosti, lipidnoho obminu ta vmistom hormoniv zhyrovoi tkanyny u khvorykh na hipotyreoz. Bukovinian Medical Herald. 2012;16,4(64):63–7. [in Ukrainian]
    • Marusyn OV, Botsiurko VI. Ozhyrinnia i leptynorezystentnist. Galician Medical Journal. 2012;19(1):155–7. [in Ukrainian]
    • Mitchenko OI, Romanov VY, Kulyk OY. Leptynorezystentnist, stan vuhlevodnoho ta lipidnoho obminiv u patsiientiv z hipertonichnoiu khvoroboiu ta metabolichnym syndromom.  Ukrainian Journal of Cardiology. 2015;2:58-64. [in Ukrainian]
    • Mishchenko N. L-tiroksin v lechenie gipotireoza: forma imeet znachenie. Zdorovya Ukrainy. Tyreoidolohiia. 2015;4(32):28. [in Russian]
    • Petunina NA, Altshuler NE, Rakova NH, Trukhina LV. Gormony zhirovoy tkani i funktsionalnaya aktivnost shchitovidnoy zhelezy. Obesity and Metabolism. 2010;4:8–11. [in Russian]
    • Zakharova SM, Savelyeva LV. Ozhirenie i gipotireoz. Obesity and Metabolism. 2013;2:54–8. [in Russian]
    • Zubkova ST. Lechenie pervichnogo gipotireoza: puti sovershenstvovaniya. Zdorovya Ukrainy. 2015;4(32):29–31. [in Russian]
    • Brenta G. Why can insulin resistance be a natural consequence of thyroid dysfunction? J. Thyroid. Res. 2011:152850. doi: 10.4061/2011/152850.
    • Didushko OM. Pathogenetic grounds for the development of insulin resistance in patients suffering from primary hypothyroidism. The Pharma Innovation. 2016;5(1):4–7.
    • Maratou E, Hadjidakis DJ, Kollias A. Studies of insulin resistance in patients with clinical and subclinical hypothyroidism. Eur J Endocrinol. 2009;160(5):785–90.
    • Perry RJ, Wang Y, Cline GW, Rabin-Court A, Song JD, Dufour S, et al. Leptin Mediates a Glucose-Fatty Acid Cycle to Maintain Glucose Homeostasis in Starvation. Cell. 2018 Jan 11; 172(1-2):234–48.
    • Shahramian I, NooriNM, Ramezani AA, Sharafi E, Akhlaghi E.  Correlation between serum leptin level and thyroid hormones in children with major beta-thalassemia. Iran J Ped Hematol Oncol. 2013;3(4):149–53.
    • Wailace AM, Mc Mahon AD, Packard CJ, Kelly A, Shepherd J, Gaw A, et al. Plasma leptin and the risk of cardiovascular disease in the west of Scotland coronary prevention study (WOSCOPS). Circulation. 2011;104:3052–60.
    • Yu D, Yu Z, Sun Q. Effects of body fat on the associations of high-molecular-weight adiponectin, leptin and soluble leptin receptor with metabolic syndrome in Chinese. PLoS One. 2011;6(2):e16818.
    Publication of the article «World of Medicine and Biology» №3(65), 2018 year, 059-063 pages, index UDK 616-08+616.441-008.64+616-056.52
    DOI 10.26724/2079-8334-2018-3-65-59-63