| About the author: |
O.V. Malikov |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The article presents structural changes of the renal medulla in experimental traumatic skin injury in rats under conditions of intravenous infusion of a colloid-hyperosmolar solution of gekoton. It was found that gekoton acts on the structure of the body as a cytoprotector. The cytoprotective effect is caused by induction of hypertrophy and hyperplasia of mitochondria. It also acts as a stimulator of mitophagia and an inhibitor of mitochondrial transduction of apoptotic signal. The obtained results are a kind of control and necessary for interpretation in comparison with the data to be obtained in the study of changes in the structural components of the renal medulla under conditions of infusion of other combined hyperosmolar solutions. |
| Tags |
burn, renal medulla, light and electron microscopy |
| Bibliography |
- Gunas, I. V., Kondratskiy, B. O., Nurmetova, I. K. Dynamika zmin endogennoyi intoksikatsii v organizmi shchuriv protyagom misyatsya pislya opiku shkiry II-III stupenya ploshcheyu 21-23 % poverkhni tila ta ikh korektsia infuziynymi rozchinami laktoproteinu z sorbitolom ta HAES-LX-5 %. Ukrainskiy morfologichniy almanakh. 2012; 10 (4): 29−34. [in Ukrainian]
- Dzevulska, I. V., Gunas, I. V., Cherkasov, E. V. Morfologicheskaya kharakteristika gistogematicheskikh barierov v organakh neyroimunnoendokrinnoy sistemy pri infuzionnoy terapii ozhogovoy bolezni kombinirovannymi giperosmolyarnymi rastvorami. Khirurgiya, Vostochnaya Evropa. 2014; 2 (10): 113−124. [in Russian]
- Kozynets, V. P., Slesarenko, S. V., Sorokina, O. M. Opikova travma ta iyi naslidky. Dnipropetrovsk, Presa Ukrayiny. 2008; 224 s. [in Ukrainian]
- Kondratskiy, B. O., Novak, B. L. Kompleksniy koloidno-giperosmolyarniy infuziyniy preparat. Patent 93776, Ukraina, MPK A61K9/08, 2011 (5); 12 s. [in Ukrainian]
- Cherkasov, V. G. Ultrastrukturnie transformatsii mezhkletochnogo veshhestva vo vnutrennikh organakh pri lechenyi ozhogovoy bolezni putyom infuzyi kombinirovannykh giperosmolyarnikh rastvorov. Klinichna anatomiya ta operativna khirurgiya. 2015; 1 (51): 37−44. [in Russian]
- Cherkasov, E. V., Kovalchuk, A. I., Dzevuska, I. V. Ultrastruktura krovenosnykh sosudov organov neyroimunnoendokrinnoy sistemy pri eksperimentalnoy ozhogovoy bolezni u krys i eyo infuzionnoy terapyi kombinirovannymi giperosmolyarnimi rastvorami. 2015; 1: 68−72. [in Russian]
- Cherkasov, E. V. Selektyvnist avtofagyi v epitelioretikuloysiyakh tymusa ta iyi rol u klitynnomu vyzhyvanni i klitynniy smerti v tymusi pry opikoviy khvorobi. Naukoviy visnyk Uzhgorodskogo Universitetu. 2012; 43: 122−126. [in Ukrainian]
- Kroemer, G., Galluxxi, L, Vandenabeele, P. Classification of cell death: recommendation of the Nomnclature Committee on the Cell Death. Cell Death Differ. 2009; 16: 1−3.
- Shen, D. F., Noris, K. L., Youle, R. Mitochondrial dynamics and apoptosis. Gens Dev. 2008; 22 (12): 1577−1590.
- Tolkovsky, A. M. Mitophagy. Biophys. Acta. 2009; 1793: 1508−1515.
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| Publication of the article |
«World of Medicine and Biology» №3(65), 2018 year, 166-169 pages, index UDK 616.61-001.17-08-091:612.08 |
| DOI |
10.26724/2079-8334-2018-3-65-166-169 |
