| About the author: |
Kharchenko А.V., Sherstyuk O.A. |
| Heading |
EXPERIMENTAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
The consequences of influence of infection of Helicobacter are in-process shown pylori on the mucous membrane of stomach. Both histological methodologies and molecular-biological methodology (ISSR-PCR) are applied with ISSR-praimer S-2, with the structure (AGC) 6G. The changes of mucous membrane of stomach are analysed at H.˚pylori- the associated diseases: chronic ulcerous illness of duodenum, chronic ulcerous illness of stomach, ulcerous infiltration cancer of stomach. Histological in the mucous membrane of stomach found out dysplasias of three degrees of weight (D-1; D-ІІ; D-ІІІ). Genotype in a mucous membrane found out changes corresponding to microsatellite expansions that are the certificate of pre-cancer changes. |
| Tags |
Helicobacter pylori, dysplasia, microsatellite expansions |
| Bibliography |
- Aruin LI, Kononov AV, Mozgovoy SI. Mezhdunarodnaya klassifikatsiya khronicheskogo gastrita: chto sleduyet prinyat i chto vyzyvayet somneniya. Arkh. pat. 2009; 4: 11 – 18. [in Russian]
- Karseladze AI. Nekotoryye osnovopolagayushchiye ponyatiya onkomorfologii v svete dostizheniy sovremennoy molekulyarnoy biologii. Arkh. pat. 2009; 5: 17– 21. [in Russian]
- Kononov AV, Mozgovoy SI, Markelova MV, Shimanskaya AG. Morfogenez atrofii slizistoy obolochki zheludka kak osnova fenotipa khronicheskogo gastrita. Arkh. pat. 2011; 3: 26 – 31. [in Russian]
- Markovskyi VD, Kharchenko OV. Kompleksna patomorfolohichna dyferentsiyna diahnostyka peredpukhlynnykh protsesiv i raku shlunka. Patolohiya. 2012; 3: 15 – 18. [in Ukrainian]
- Kharchenko OV. Dynamika proyaviv fenotypu dysplaziy epiteliyu slyzovoyi obolonky shlunka u vidpovidnosti z yikh henotypom na materiali vyvchennya svitlovoyi mikroskopiyi ta DNK-typuvannya za metodom ISSR-PCR. Visnyk morfolohiyi (Reports of Morphology). 2009; 15(2): 396 – 402. [in Ukrainian]
- Kharchenko OV. Mikrosatelitni ekspansiyi – molekulyarno-biolohichnyi fenomen diahnostyky peredpukhlynnykh i pukhlynnykh protsesiv. Svit medytsyny ta biolohiyi. 2015; 2(49): 196 – 200. [in Ukrainian]
- Haruma K., Okamoto S., Kawaguchi H. Reduced incidence of Helicobacter pylori infection in young Japanese persons between the 1970s and 1990s. – J.Clin.Gastroenterol. – 1997. – V. 25 – P. 583 – 6.
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| Publication of the article |
«World of Medicine and Biology» №3(65), 2018 year, 196-199 pages, index UDK 616. 33 |
| DOI |
10.26724/2079-8334-2018-3-65-196-199 |
