S.V. Pylypenko, A.A. Koval, V.V. Makarchuk

IMPACT OF MULTIPROBIOTICS ON THE CONTENT OF TBA-REACTIVE SUBSTANCES IN THE BLOOD SERUM AND MUCOUS MEMBRANES OF THE STOMACH AND COLON IN RATS WITH LONG-TERM GASTRIC HYPOCHLORHYDRIA

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About the author:	S.V. Pylypenko, A.A. Koval, V.V. Makarchuk
Heading	BIOLOGY
Type of article	Scentific article
Annotation	It has been established that after 28 days of administering omeprazole to rats, the TBARS content had grown in all the studied media: in the blood serum, by 92.1% (p <0.001); in the gastric mucosa, by 352.4% (p < 0.001) and in the mucous membrane of the colon, by 57.3% (p <0.01) compared to that of the control group. Under the conditions of the concomitant 28-day administration of omeprazole and Simbiter multiprobiotic, the TBARS content in the blood serum was the same as that in the control group rats. After 28 days of co-administering omeprazole and the “Apibact” multiprobiotic, the TBARS content in the blood serum was even by 41.4% (p <0.05) lower than that in the control group. After 28 days of co-administering of omeprazole and Simbiter multiprobiotic, the TBARS content in the rat gastric mucosa was by 64.4% (p <0.01) lower than in the group of rats given omeprazole only. In the concomitant administration of the “Apibact” multiprobiotic with omeprazole, the TBARS content in the gastric mucosa was by 57.8% (p <0.01) smaller in comparison with the same value in the group of rats, which was administered omeprazole only for 28 days. "Simbiter" and "Apibact" multiprobiotics in the conditions of the 28-day concomitant administration with omeprazole reduced the TBARS content in the colon mucous membrane by 18.4% (p <0.05) and 39.0% (p <0, 05), respectively.
Tags	hypochlorhydria, probiotics, TBA-reactivesubstances (TBARS), mucous membrane of the stomach, mucous membrane of the colon
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Publication of the article	«World of Medicine and Biology» №3(65), 2018 year, 218-222 pages, index UDK 615.24:591.41/.434]:599.323.4
DOI	10.26724/2079-8334-2018-3-65-218-222