Volosovets A.O., Zozulya I.S.

INVESTIGATION OF THE INTERNAL RISK FACTORS INFLUENCE ON THE TIME OF THE ISCHEMIC STROKE ONSET

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About the author:	Volosovets A.O., Zozulya I.S.
Heading	CLINICAL MEDICINE
Type of article	Scentific article
Annotation	The purpose of the present study was to determine the effect of internal modified risk factors at the time of the ischemic stroke onset. We performed a clinical, neurological and neuroimaging study of 300 patients who suffered an acute ischemic stroke (men - 196, women - 104) aged 42 to 84 years (average age - 65.2 ± 8.7 years). The factor of arterial hypertension was observed among all groups of patients. Тhe factor of the arrhythmia had a clear association with the daytime and evening period of occurance of stroke (groups 1 and 2), which is exactly the same as the appearance of the cardioembolic subtype of ischemic stroke. The factor of atherosclerosis has demonstrated great importance for all groups. At the same time, the factor of diabetes showed a significant increase just for patients in group 3 (82.9%), which confirms the association of glycemic metabolic disorders with autonomic vascular regulation at night. The predictor of overweight has shown a strong presence in all patients, but a clear tendency prevalence is in the 2nd and 3rd groups. The level of cholesterol among patients with stroke, had a slightly different trend - in the 1st group there was an insignificant level of hypercholesterolemia (5.4 ± 0.5 mmol / l); In the 2nd group was higher level of hypercholesterolemia (7.3 ± 0.7 mmol / l); In the 3rd group, despite the relative prevalence of overweight, we have discovered a moderate level of hypercholesterolemia (5.8±0.5 mmol/l). Internal risk factors play an important role in the occurrence of cerebral ischemia. Also they have shown high level of nonspecificity in detecting the effect on the time of stroke onset.
Tags	stroke, time of occurrence, internal risk factors
Bibliography	Zozulya AI, Zozulya IS, Volosovets AA. Oslozhneniya ishemicheskogo insul'ta: diagnostika, lecheniye, profilaktika i reabilitatsiya. Psikhiatriya, psikhoterapiya i klin. psikhologiya. 2017; 8(3):375-81. [in Russian] Mishchenko TS. Epidemiologiya tserebrovaskulyarnykh zabolevaniy i organizatsiya pomoshchi bol'nym s mozgovym insul'tom v Ukraine. Ukr. vísn. psikhonevrologíí. 2017; 25(1):22-4. [in Russian] Adamsson Eryd S, Gudbjornsdottir S, Manhem K, Rosengren A, Svensson AM, Miftaraj M, et al. Blood pressure and complications in individuals with type 2 diabetes and no previous cardiovascular disease: national population based cohort study. BMJ. 2016 Aug 4; 354:i4070. Cai A, Zhong Q, Liu C, Zhou D, Li X, Zhang Y, et al. Associations of systolic and diastolic blood pressure night-to-day ratios with atherosclerotic cardiovascular diseases. Hypertens Res. 2016 Dec; 39(12):874-878. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. 2002 Jul 6; 360(9326):7-22. Mancia G, Fagard R, Narkiewicz K, Redon J, Zanchetti A, Bohm M, et al. 2013 ESH/ESC Guidelines for the management of arterial hypertension: the Task Force for the management of arterial hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC). J Hypertens. 2013 Jul; 31(7):1281-357. Singer DE, Albers GW, Dalen JE, Go AS, Halperin JL, Manning WJ. Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 2004 Sep; 126(3 Suppl):429S-56S. Segula D. Complications of obesity in adults: a short review of the literature. Malawi Med J. 2014; 26(1):20-4. Tsivgoulis G, Safouris A, Kim DE, Alexandrov AV. Recent Advances in Primary and Secondary Prevention of Atherosclerotic Stroke. J Stroke. 2018; 20(2):145-166.
Publication of the article	«World of Medicine and Biology» №1(67), 2019 year, 021-024 pages, index UDK 616-071.1.616-056.8.616.831-005.6
DOI	10.26724/2079-8334-2019-1-67-21