| About the author: |
V.V. Mavrutenkov, Y.K. Bolbot, O.V. Shvaratska, O.V. Kazatska |
| Heading |
CLINICAL MEDICINE |
| Type of article |
Scentific article |
| Annotation |
Medical case histories of two male infants born naturally, in term, who developed neonatal Herpes simplex virus type 2 (HSV-2) infections are discussed. Mothers of both infants presented with signs of vesicular rash in the anogenital area at the time of parturitions. In both cases the presented HSV-2 infection had intranatal transmission route. Clinical course of infection was notable for recurrent vesicular rash with no signs of fever or systemic disorders. Both infants were prescribed continuous systemic acyclovir therapy from the early age for over a year. In both cases long-term course of acyclovir was well tolerated and led to long-lasting control of the infection. Therefore such therapeutic regimen might be preferable to the intermittent short-term courses for exacerbations of HSV-1 and HSV-2 infections in infants. Assessment of efficacy and optimal duration of the treatment should be mainly determined by clinical indications. |
| Tags |
neonatal HSV infection, acyclovir, infants, treatment |
| Bibliography |
- Bradley JS, Nelson JD, editors. Nelson's Pediatric Antimicrobial Therapy. 22nd ed. Elk Grove Village, IL: AAP; 2016. 278 p.
- Harris JB, Holmes AP. Neonatal herpes simplex viral infections and acyclovir: an update. J Pediatr Pharmacol Ther. 2017;22(2):88–93. DOI: 10.583/1551-6776-22.2.88.
- James SH, Kimberlin DW. Neonatal herpes simplex virusinfection: epidemiology and treatment. Clin Perinatol.2015 Mar;42(1):47-59. DOI: 10.1016/j.clp.2014.10.005.
- Kato K, Hara S, Kawada J, Ito Y. Recurrent neonatal herpes simplex virus infection with central nervous system disease after completion of a 6-month course of suppressive therapy: Case report. J Infect Chemother. 2015 Dec;21(12):879-81. doi: 10.1016/j.jiac.2015.08.005.
- Kimberlin DW, Baley J. Guidance on management of asymptomatic neonates born to women with active genital herpes lesions. Pediatrics [Internet]. 2013 Feb [cited 2018 Mar 27];131(2):e635-46. Available from: http://pediatrics.aappublications.org/content/ 131/2/e635 DOI: 10.1542/peds.2012-3216.
- Kimberlin DW, Brady MT, editors. RedBook: 2015 Report of the Committee on Infectious Diseases. 30th ed. Elk Grove Village, IL: AAP; 2015. Herpes simplex; p. 432-45.
- Looker KJ, Magaret AS, Turner KME, et al. Global estimates of prevalent and incident herpes simplex virus type 2 infections in 2012. PLoS ONE. 2015 Jan 21;10(1):e114989. DOI: 10.1371/journal.pone.0114989.
- Looker KJ, Margaret AS, May MT, et al. Global and regional estimates of prevalent and incident herpes simplex virus type 1 infections in 2012. PLoS ONE.2015 Oct 28;10(10):e0140765. DOI: 10.1371/journal.pone.0140765.
- Mandell GL, Bennett JE, Dolin R, editors. Mandell, Douglas, and Bennett's principles and practice of infectious diseases. 7th ed. Philadelphia, PA:Churchill Livingstone/Elseiver; 2010. 4028 p.
- Neonatal HSV infection / Neonatal Guide [Internet]. Auckland: The New Zealand Herpes Foundation; 2013 [updated 2014 July 15; cited 2018 Apr 5]. Available from: https://www.herpes.org.nz/files/1814/0010/8656/GH_2013_neonatal.pdf.
- Pinninti SG, Kimberlin DW. Neonatal herpes simplex virus infections. Pediatr Clin North Am. 2013 Apr;60(2):351-65. DOI: 10.1016/j.pcl.2012.12.005.
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| Publication of the article |
«World of Medicine and Biology» №1(67), 2019 year, 069-073 pages, index UDK 616.523‒053.31‒085:612.017:615.281.8‒027.236 |
| DOI |
10.26724/2079-8334-2019-1-67-69 |
